新辅助化疗对低位直肠癌化疗疗效及手术效果的影响  

Effect of neoadjuvant chemotherapy on chemotherapy and Clinical outcome of low rectal cancer surgery combined with neoadjuvant chemotherapy

作　　者：高树全[1] 薛军[1] 张迎春[1] 崔大鹏[1] 范露露[1] 刘振显[1] Gao Shuquan;Xue Jun;Zhang Yingchun;Cui Dapeng;Fan Lulu;Liu Zhenxian(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Hebei North University,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院肝胆外科,河北张家口075000

出　　处：《中华普外科手术学杂志（电子版）》2020年第2期155-157,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：河北省卫生厅科研基金项目(编号:20180813)。

摘　　要：目的探讨规范化新辅助化疗(NC)治疗低位直肠癌的化疗疗效及对手术效果的影响。方法选取2016年10月至2018年10月接受治疗的96例低位直肠癌患者为研究对象,按照随机数表分为两组,开腹组行开腹手术治疗,NC组术前添加规范化NC,治疗后行开腹手术,各48例。采用SPSS23.0软件对数据进行统计学分析。术中术后指标采用(x±s)描述,采用独立t检验;术后并发症发生率比较采用χ^2检验,P<0.05为差异有统计学意义。结果NC组淋巴结清扫数目、远切端长度显著高于开腹组淋巴结清扫数目、远切端长度(P<0.05)。两组患者手术时间、术中出血量差异无统计学意义(P>0.05);NC组术后排气时间、术后进食时间显著优于开腹组(P<0.05)。NC组术后并发症总发生率为12.5%,显著低于开腹组术后并发症总发生率29.2%,差异有统计学意义(P<0.05)。结论规范化新辅助化疗联合常规开腹手术治疗能够增加淋巴结清扫数目、远切端长度,改善患者术后排气时间和进食时间,降低术后并发症发生率,适合临床推广应用。Objective To investigate the efficacy of standardized neoadjuvant chemotherapy(NC)in the treatment of low rectal cancer and its effect on surgical outcomes.Methods 96 patients with low rectal cancer who were treated from October 2016 to October 2018 were enrolled into the study.According to the random number table.48 cases were divided into the routine group,who received conventional open surgery,while 48 cases were divided into the NC group,who underwent standardized new adjuvant chemotherapy before open surgery.Statistical analysis were performed by using SPSS 23.0 software.Measurement data such as intraoperative and postoperative indexes were represented as (x±s) and were examined by using t test.Conversion rate and postoperative complication rate were analyzed by usingχ^2 test.A P value of<0.05 was considered as statistical significant difference.Results The number of dissected lymph nodes and the length of distal margin in the NC group were significantly better than those in the conventional group respectively(P<0.05).There were no significant difference between two groups in terms of operation time and intraoperative blood loss(P>0.05).The postoperative exhaust time and postoperative feeding time in the NC group were significantly better than those in the conventional group respectively(P<0.05).The total incidence of postoperative complications in the NC group was 12.5%,which was significantly lower than 29.2%in the conventional group,with significant difference(P<0.05).Conclusion Standardized neoadjuvant chemotherapy combined with conventional open surgery could increase the number of dissected lymph nodes,the length of the distal margin,and could improve the postoperative exhaust time and eating time,could reduce the incidence of postoperative complications,which is worth of clinical promotion.

关 键 词：直肠肿瘤 化学疗法 辅助 外科手术 治疗结果 

分 类 号：R735.37[医药卫生—肿瘤]