血脂水平与不同类型老年期抑郁症的相关性  

Analysis of the Relationship between the Levels of Different Blood Lipid Components and Depression in the Elderly

作　　者：苏翔宇 许秀峰[1] 张闻宇 程宇琪 沈宗霖[1] 陈娴瑜 姜红燕[1] SU Xiang-yu;XU Xiu-feng;ZHANG Wen-yu;CHEN Yu-qi;SHEN Zong-lin;CHEN Xian-yu;JIANG Hong-yan(The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650031,China)

机构地区：[1]昆明医科大学第一附属医院精神科,云南昆明650031

出　　处：《昆明医科大学学报》2020年第2期64-67,共4页Journal of Kunming Medical University

基　　金：云南省卫生科技计划项目(2018NS0018)。

摘　　要：目的分析老年期抑郁症的血脂水平,探讨不同类型的老年期抑郁症与血脂水平的关系。方法入组昆明医科大学第一附属医院精神科住院部老年期抑郁症患者85例,招募了社区正常对照100例,采用HAMD评估患者的抑郁症状严重程度,分析比较老年期抑郁症患者与正常对照组、轻中度老年期抑郁症与重度老年期抑郁症组;早发老年期抑郁症组和迟发老年期抑郁症组血脂水平的差异及特点。结果老年期抑郁症组患者血浆总胆固醇TC(4.45±0.88,4.95±0.90,P<0.001)、LDL-C(2.74±0.78,3.01±0.80,P=0.03显著低于正常对照组,而甘油三酯TG(1.74±1.34,1.78±0.93,P=0.81)、HDL-C(1.32±0.39,1.40±0.42,P=0.17)的水平与正常对照组相比较差异无统计学意义(P>0.05)。轻中度抑郁组与重度抑郁组的各血脂水平相比较、早发老年期抑郁症组与迟发老年期抑郁症组的各血脂水平比较,差异均无统计学意义(P>0.05)。结论老年期抑郁症患者与正常老年人相比,有着更低TC和LDL-C水平,低TC和低LDL-C,尤其是低TC可能是LLD的潜在风险因素。不同抑郁程度的患者组之间、早发老年期抑郁症组和迟发老年期抑郁症组之间各血脂水平未见统计学差异,表明血脂与抑郁程度以及首发年龄之间无显著关联。Objective The purpose of this study is to explore the relationship between plasma lipid levels and late-life depression(LLD).Methods Eighty-five late-life depression patients were recruited in the 1st Affiliated Hospital of Kunming Medical University and 100 controls were recruited from local community.After an overnight fasting state of 12 h they underwent blood drawing for triglyzerides(TG),total cholesterol,low-density lipoprotein(LDL)-and high-density lipoprotein(HDL)-cholesterol measurements.HAMD score was used to measure the depressive severity of the patients.We analyzed the differences and characteristics of plasma lipid levels between the LLD and controls,mild-to-moderate LLD and major LLD,EOD and LOD.Results The levels of cholesterol(4.45±0.88,4.95±0.90,P<0.001)and LDL-C(2.74±0.78,3.01±0.80,P=0.03in late-life depression patients were significantly lower than those in the controls.However,there was no significantly difference in the levels of TG(1.74±1.34,1.78±0.93,P=0.81)、HDL-C(1.32±0.39,1.40±0.42,P=0.17)between late-life depression patients and the controls.In addition,there was no significant difference in plasma lipid levels between mild-to-moderate LLD and major LLD,EOD and LOD.Conclusion Late-life depression patients have lower cholesterol and LDL-C levels compared with the normal elderly,which shows a certain relationship between plasma lipid and LLD.Low cholesterol and low LDL-C may be potential risk factors for LLD,especially low cholesterol.

关 键 词：老年期抑郁症 血脂 低总胆固醇血症 早发型老年期抑郁症 迟发型老年期抑郁症 

分 类 号：R749[医药卫生—神经病学与精神病学]