氧瓶燃烧-电位滴定法测定盐酸头孢噻呋的氯含量  

Determination of Chlorine Content in Ceftiofur Hydrochloride by Oxygen Flask Combustion-Potentiometric Titration

作　　者：陆连寿[1] 张秀英[1] 温芳[1] 李翠[1] 蒋卉[1] LU Lian-shou;ZHANG Xiu-ying;WEN Fang;LI Cui;JIANG Hui(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2020年第3期32-35,共4页Chinese Journal of Veterinary Drug

摘　　要：建立了氧瓶燃烧-电位滴定法测定盐酸头孢噻呋中氯含量的方法。通过氧瓶燃烧法将盐酸头孢噻呋中氯转化成无机形态的氯,再通过电位滴定法定量分析吸收液中的氯含量。该方法的回收率在99.0%~105.0%之间,回收率符合要求。元素分析法测定的氯含量与氧瓶燃烧-电位滴定法测定的氯含量相一致。该方法适用于水溶性差的药物中氯含量的测定。To establish a method for the determination of chlorine content in ceftiofur hydrochloride by oxygen flask combustion-potentiometric titration,the chlorine in ceftiofur hydrochloride was converted into inorganic chlorine by oxygen flask combustion method,and then the chlorine content in the absorption solution was quantitatively analyzed by potentiometric titration.The recovery rate of the method is between 99.0% and 105.0%.The recovery rate meets the requirements.The chlorine content measured by elemental analysis was consistent with that measured by oxygen flask combustion-potentiometric titration.This method is suitable for the determination of chlorine content in poorly water-soluble drugs.

关 键 词：氧瓶燃烧 电位滴定 银量法 水溶性 氯含量 

分 类 号：S859.796[农业科学—临床兽医学]