抗苗勒管激素与男性不育疾病相关性的研究进展  

Research progress on the correlation between anti-mullerian hormone and male infertility

作　　者：杨雨阳 余鹏 谢德高 滕若冰[2] YANG Yu-yang;YU Peng;XIE De-gao;TENG Ruo-bing(Department of Urology,Affiliated Hospital of Guilin Medical University,Guangxi Zhuang Autonomous Region,Guilin541000,China;Reproduction Center,Affiliated Hospital of Guilin Medical University,Guangxi Zhuang Autonomous Region,Guilin541000,China)

机构地区：[1]桂林医学院附属医院泌尿外科,广西桂林541000 [2]桂林医学院附属医院生殖中心,广西桂林541000

出　　处：《中国当代医药》2020年第6期22-25,31,共5页China Modern Medicine

基　　金：广西壮族自治区桂林市科学研究与技术开发计划项目(2016012706-3)。

摘　　要：抗苗勒管激素(AMH)也称苗勒管抑制物(MIS),由未成熟睾丸支持细胞和卵巢颗粒细胞的不同时期分泌进入血液循环并发挥独特的生理作用。男性中,AMH主要参与了胚胎苗勒管的消退、男性睾丸发育、调节精子发生等过程,上述生理过程中出现异常均可造成男性不育。精子发生的过程依赖支持细胞的微环境,支持细胞作为男性AMH唯一来源,AMH一定程度上反映睾丸生精上皮功能进而提示男性生育能力水平。本文就AMH与男性不育疾病的相关性作一综述。Anti-mullerian hormone,also known as mullerian inhibiting substance,is secreted into the blood circulation by immature testicular Sertoli cells and ovarian granulosa cells at different periods and plays its unique physiological role.In men,AMH is mainly involved in the regression of embryonic mullerianduct,male testicular development,regulation of sperm production and other processes,and the abnormality of above physiological process could cause male infertility.The process of sperm production relies on microenvironment of Sertoli cells,which are the only source of AMH in male and AMH partly reflects the spermatogenic epithelial function of testes to a certain extent,thus suggesting the level of fertility in men.This article reviews the correlation between AMH and male infertility.

关 键 词：抗苗勒管激素 男性不育 苗勒管永存综合征 精子参数 隐睾症 克氏综合征 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]