Keratograph 5M眼表综合分析仪观察鼻咽癌放疗患者泪膜及睑板腺功能的变化  

The changes of tear film and meibomian gland function in radiotherapy patients

作　　者：张俐娜[1] 李肖春[1] 吕志刚[1] 胡望远[1] 周玲[1] Zhang Lina

机构地区：[1]浙江省金华市中心医院,321000

出　　处：《浙江临床医学》2020年第1期30-32,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省金华市科技局社会发展类重点项目(2015-3-011)。

摘　　要：目的应用Keratograph 5M眼表综合分析仪观察放疗对鼻咽癌患者泪膜及睑板腺功能的影响.方法2016年1月至2017年12月放疗科确诊为鼻咽癌行放疗半年内的患者25例(50眼)为放疗组,同期非鼻咽癌放疗患者30例(60眼)为对照组.使用Keratograph 5M非侵入性眼表综合分析仪进行非侵入式泪河高度(NITMH)、首次泪膜破裂时间(NITBUTf)、平均泪膜破裂时间(NITBUTav)、睑板腺缺失评分及泪膜脂质层厚度分级检查.结果放疗组与对照组比较,NITBUTf及NITBUTav缩短,睑板腺缺失评分升高,泪膜脂质层厚度分级下降,差异有统计学意义.两组间NITMH比较,差异无统计学意义.结论鼻咽癌患者放疗后会出现睑板腺腺体丢失和泪膜稳定性下降,从而更易引起干眼的发生.Purpose To investigate the influence of nasopharyngeal carcinoma radiotherapy on tear film and meibomian gland function by Keratograph 5M ocular surface analyzer.Methods 25 patients(50 eyes)who received radiotherapy for nasopharyngeal carcinoma and 30 age-matched control subjects(60 eyes)were evaluated from January 2016 to December 2017.Subjects underwent non-invasive tear meniscus height(NITMH),first non-invasive tear film break-up time(NITBUTf),average non-invasive tear film break-up time(NITBUTav),meibomian gland dropout scores and tear film lipid layer thickness using Keratograph 5M ocular surface analyzer.Results Radiotherapy group’s NITBUTf,NITBUTav and tear film lipid layer thickness were lower than those in control group(P<0.05),but had higher meibomian gland dropout scores than control group(P<0.05).The NITMH of radiotherapy group and control group were compared,it was no statistical significant difference(P>0.05).Conclusions Nasopharyngeal carcinoma patients that received radiotherapy exhibited meibomian gland dysfunction and tear film instability,contributing to dry eye symptoms.

关 键 词：Keratograph 5M眼表综合分析仪 鼻咽癌 放疗 泪膜 睑板腺功能 

分 类 号：R73[医药卫生—肿瘤]