基于SEER数据库对恶性胸膜间皮瘤预后相关因素分析  

作　　者：董良[1] 赵建刚[1] 王伟英[1] 彭登付 葛丽娜[1] 

机构地区：[1]中国医科大学绍兴医院,312030

出　　处：《浙江临床医学》2020年第1期97-99,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨恶性胸膜间皮瘤的临床病理特征及预后,评估影响恶性胸膜间皮瘤生存的预测因子,为制定治疗方案,评估患者的预后提供参考.方法筛选SEER数据库2010至2015年恶性胸膜间皮瘤病例.分析预后与性别、年龄、TNM分期、手术、化疗等变量之间的关系.结果2010至2015年符合条件的患者1959例,单因素分析显示性别、年龄、组织类型、TNM分期,手术、放疗、化疗是恶性胸膜间皮瘤生存的预测因子,Cox回归分析显示年龄(总体P<0.001,与≤60岁组相比,61~70岁组,HR 1.214,95%CI:1.032~1.427,P=0.019;71~80岁组:HR 1.416,95%CI:1.207~1.661,P<0.001;≥81岁组:HR 1.620,95%CI:1.350~1.943,P<0.001),组织类型(总体P<0.001,与恶性间皮瘤未分型组相比,恶性肉瘤样间皮瘤,HR 1.834,95%CI:1.567~2.146,P<0.001;恶性上皮样间皮瘤:HR 0.764;95%CI:0.679~0.859,P<0.001;恶性双相型间皮瘤:HR 1.217,95%CI:1.024~1.447,P<0.001),T分期(总体P<0.001,与T1组相比,T2组HR 1.777,95%CI:1.322~2.293,P<0.001;T3组HR 1.325,95%CI:0.973~1.804,P=0.074;T4组HR 1.524,95%CI:1.133~2.051,P<0.001;Tx组HR 1.643,95%CI:1.244~2.170,P<0.001),M分期(与M0相比,M1组HR 1.494,95%CI:1.248~1.789,P<0.001),手术(与手术组相比,HR:1.333,95%CI:1.183~1.502,P<0.001),化疗(与化疗组相比,HR:1.541,95%CI:1.383~1.716,P<0.001)和性别(与女性相比,HR:1.282,95%CI:1.133~1.450,P<0.001)是恶性胸膜间皮瘤生存的独立预测因子.结论年龄、性别、组织类型等是恶性胸膜间皮瘤生存的独立预测因子.Objective To explore the clinicopathologic features and prognosis of malignant pleural mesothelioma,assess the factors affecting the prognosis,and provide a reference for the development of treatment programs and evaluation of patients’prognosis.Methods The cases of malignant pleural mesothelioma reported to the National Cancer Institute’s Surveillance,Epidemiology and End-results(SEER)program between 2010 and 2015 were included in this analysis.The relationship between prognosis and sex,age,TNM stage,surgery,chemotherapy and other variables were analyzed.Results There were 1959 cases of malignant pleural mesothelioma included in this study.The results of univariate analysis showed that sex,age at diagnosis,the type of tumor,the TNM stage,surgery,chemotherapy,radiotherapy were significantly related to the survival rate of the patients.The results of multivariate Cox analysis revealed that age at diagnosis(overall P<0.001),the type of tumor(overall P<0.001),stage of T(overall P<0.001),stage of M(distant metastasis,HR 1.494,P<0.001),surgery(non-surgery,HR:1.333,P<0.001),chemotherapy(non-chemotherapy,HR:1.541,P<0.001)and sex(male,HR:1.282,P<0.001)were the independent prognostic factors of malignant pleural mesothelioma.Conclusion Older age,larger tumor size,male gender,poor differentiation are significant prognostic risk factors of malignant pleural mesothelioma.

关 键 词：恶性胸膜间皮瘤 预后 危险因素 SEER数据库 

分 类 号：R73[医药卫生—肿瘤]