上消化道出血患者奥美拉唑联合乌司他丁治疗对患者血清IL-6、TNF-α水平的影响  

Effects of omeprazole combined with ulinastatin on serum levels of IL-6 and TNFalpha in patients with upper gastrointestinal bleeding

作　　者：张曜文 艾宽宽[1] 王聪[1] 王佩影 薛红璐 杨峰[1] 孙富强[1] Zhang Yaowen;Ai Kuankuan;Wang Cong;Wang Peiying;Xue Honglu;Yang Feng;Sun Fuqiang(Department of Gastroenterology,Hospital Affiliated to Jining Medical College,Jining 272000,China)

机构地区：[1]济宁医学院附属医院消化内科,272000

出　　处：《国际医药卫生导报》2020年第6期826-829,共4页International Medicine and Health Guidance News

摘　　要：目的探究上消化道出血患者奥美拉唑联合乌司他丁治疗对患者血清IL-6、TNF-α水平的影响。方法选取2016年01月至2019年01月本院收治的106例上消化道出血患者作为研究对象,并依据不同的治疗方案分为两组,各53例。对照组采用奥美拉唑治疗,研究组则在对照组基础上加以采用乌司他丁治疗。比较两组临床治疗效果以及炎症反应情况、血尿淀粉酶以及白细胞计数的恢复时间,并进行评估、分析。结果治疗后,研究组血清中IL-6、IL-8、TNF-α、CRP水平分别为(175.3±30.6)ng/L、(124.4±10.0)ng/L、(284.4±60.0)ng/L、(3.0±2.4)mg/L,均低于对照组(214.5±26.5)ng/L、(156.4±11.4)ng/L、(372.2±59.1)ng/L、(4.4±1.0)mg/L,差异均有统计学意义(均P<0.05);研究组血尿淀粉酶恢复时间为(5.1±1.2)d,低于对照组(7.2±2.4)d,白细胞计数恢复时间为(6.3±1.7)d,高于对照组(4.5±1.4)d,差异均有统计学意义(均P<0.05);研究组总有效率为98.1%,高于对照组84.9%,差异有统计学意义(P<0.05)。结论在临床治疗上消化道出血当中,采用奥美拉唑联合乌司他丁,不仅临床效果显著,还可有效改善患者机体恢复情况以及炎症反应情况,较单一使用奥美拉唑来说,联合用药疗效更为确切,并且安全性比较高,值得在临床当中大力推广以及使用。Objective To investigate the effect of omeprazole combined with ulinastatin on serum levels of IL-6 and TNF-alpha in patients with upper gastrointestinal bleeding.Methods 106 patients with upper gastrointestinal bleeding admitted to our hospital from January,2016 to January,2019 were selected as study objects,and were divided into a control group and a study group according to the treatment schemes,with 53 cases in each group.The control group was treated with omeprazole,and the study group was treated with ulinastatin and omeprazole.The clinical therapeutic effect,inflammatory response,hematuria amylase,and recovery time of white blood cell count of the two groups were compared and evaluated.Results After the treatment,the serum levels of IL-6,IL-8,TNF-α,and CRP were lower in the study group than in the control group[(175.3±30.6)ng/L vs.(214.5±26.5)ng/L,(124.4±10.0)ng/L vs.(156.4±11.4)ng/L,(284.4±60.0)ng/L,(372.2±59.1)ng/L,and(3.0±2.4)mg/L vs.(4.4±1.0)mg/L;all P<0.05].The recovery times of hematuria amylase and white blood cell count were shorter in in the study group than in the control group[(5.1±1.2)d vs.(7.2±2.4)d and(6.3±1.7)d vs.(4.5±1.4)d;both P<0.05].The curative effective rate was higher in the study group than in the control group(98.1%vs.84.9%;P<0.05).Conclusions Omeprazole combined ulinastatin in the clinical treatment of upper gastrointestinal bleeding is remarkably effective and can effectively improve the patients’body recovery and inflammatory reaction.The combination is more effective and safer than omeprazole alone,so it is worth being clinically generalized.

关 键 词：上消化道出血 奥美拉唑 乌司他丁 炎症因子 

分 类 号：R573[医药卫生—消化系统]