99Tcm -SC SPECT与CT-LG同机融合显像检测兔VX2乳腺癌腋窝前哨淋巴结  

99Tc m-SC SPECT and CT lymphography fusion imaging for detecting axillary sentinel lymph node of VX2 breast cancer rabbit models

作　　者：王博[1] 王攀鸽 李彦鹏[3] 肖慧娟[1] 谭红娜 WANG Bo;WANG Pange;LI Yanpeng;XIAO Huijuan;TAN Hongna(Department of Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Radiology,Children's Hospital Affiliated of Zhengzhou University,Zhengzhou 450053,China;Department of Nuclear Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Radiology,the People's Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学第一附属医院放射科,河南郑州450052 [2]郑州大学附属儿童医院放射科,河南郑州450053 [3]郑州大学第一附属医院核医学科,河南郑州450052 [4]郑州大学人民医院放射科,河南郑州450003

出　　处：《中国医学影像技术》2020年第3期367-371,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金青年基金项目(81401378)。

摘　　要：目的探讨锝99m标记硫胶体(99 Tc m-SC)SPECT与CT淋巴管造影(CT-LG)同机融合显像VX2乳腺癌兔腋窝前哨淋巴结(SLN)的价值。方法取20只雌性新西兰大白兔建立VX2乳腺癌动物模型。对模型兔分别行CT-LG和99 Tc m-SC SPECT与CT-LG同机融合检查显示腋窝SLN,并与常规SLN活检(SLNB)和淋巴结清扫手术结果进行对比。结果20只实验兔建模成功率为95.00%(19/20)。19只实验兔均完成CT-LG和99 Tc m-SC SPECT与CT-LG同机融合检查。CT-LG检查和融合显像清楚显示SLN及其引流淋巴管的比例为78.95%(15/19)和73.68%(14/19),差异无统计学意义(P>0.05)。CT-LG检出16枚SLN,7枚非SLN(n-SLN);融合显像检出20枚SLN,12枚n-SLN;SLNB检出21枚SLN,17枚n-SLN;3种方法检出腋窝淋巴结的数目差异无统计学意义(χ2=1.497,P=0.454)。结论99 Tc m-SC SPECT与CT-LG同机融合检查可有效检出和准确定位VX2乳腺癌兔腋窝SLN,有望为临床准确识别及定位SLN提供新的检查方法。Objective To explore the value of 99 Tc m-sulfur colloid(99 Tc m-SC)SPECT and CT lymphography(CT-LG)fusion imaging for detecting axillary sentinel lymph node(SLN)of VX2 breast cancer rabbit models.Methods Totally 20 purebred female New Zealand white rabbits were used to establish models of VX2 rabbit breast cancer.CT-LG and 99 Tc m-SC SPECT and CT-LG fusion imaging examinations were performed,and the outcomes were compared with the results of SLN biopsy(SLNB)and axillary lymphadenectomy.Results The success rate of model establishment was 95.00%(19/20).Nineteen bearing cancer rabbits completed examinations of CT-LG,99 Tc m-SC SPECT and CT-LG fusion imaging,and the percentage of rabbits with both SLN and lymph ducts mapping on CT-LG and the fusion imaging was 78.95%(15/19)and 73.68%(14/19),respectively(P>0.05).There were 16 SLN and 7 non-SLN(n-SLN)on CT-LG,20 SLN and 12 n-SLN on fusion imaging,while 21 SLN and 17 n-SLN were detected with SLNB.There was no statistical difference among three examination methods for detecting axillary SLN(χ2=1.497,P=0.454).Conclusion Using fusion imaging of 99 Tc m-SC SPECT and CT-LG can detect and locate axillary SLN of VX2 breast cancer rabbit models,which could offer a new method for accurate identification and localization of SLN.

关 键 词：前哨淋巴结 锝 体层摄影术 发射型计算机 单光子 淋巴系造影 

分 类 号：R-332[医药卫生] R817.4