组织因子在肺癌中的研究进展  

Research Progress on Tissue Factor in Lung Cancer

作　　者：陈倩倩 范理宏[2] CHEN Qian-qian;FAN Li-hong(Nantong University Medical College,Nantong 226019,China;The 10th People's Hospital,Shanghai 200003,China)

机构地区：[1]南通大学医学院,江苏南通226019 [2]上海市第十人民医院,上海200003

出　　处：《肿瘤学杂志》2020年第1期62-66,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金面上项目(81473469);国家自然科学基金面上项目(31770131);上海市卫计委项目(ZHYY-ZXYJHZX-201607)。

摘　　要：组织因子(TF),又称凝血因子Ⅲ、凝血酶原或CD142,是外源性凝血系统的启动因子。TF参与许多细胞内信号传导,如细胞存活、基因和蛋白表达、增殖、血管生成等。近年来,随着对TF研究的深入,人们发现其不仅可以激活机体的凝血系统,还参与肺癌、乳腺癌等肿瘤的恶性生物学行为。全文重点对肺癌中组织因子的表达以及在肺癌中的作用机制作一综述。Tissue factor(TF),also known as coagulation factor Ⅲ,prothrombin or CD142,is the priming factor of exogenous coagulation system. In addition,TF is also involved in several intracellular signal transduction,such as cell survival,gene and protein expression,proliferation,angiogenesis and so on. In recent years,with the further study of TF,it has been found that it can not only activate the coagulation system of the body,but also participate in the malignant biological behavior of lung cancer,breast cancer and other tumors. This article reviews the expression of tissue factor and mechanism in lung cancer.

关 键 词：组织因子 肺癌 作用机制 

分 类 号：R734.2[医药卫生—肿瘤]