儿童首发抑郁症患者血清维生素D与白介素-6水平的相关性  

Study on serum vitamin D and interleukin-6 levels in children with first-episode depression

作　　者：冯虹[1] 甘建光 秦国兴[1] 潘友让 FENG Hong;GAN Jian'guang;QIN Guoxing;PAN Yourang(Department of Psychosomatic Disorders,Shaoxing 7th People's Hospital in Zhejiang Province,Shaoxing312000,China)

机构地区：[1]浙江省绍兴市第七人民医院心身障碍科,浙江绍兴312000

出　　处：《中国现代医生》2020年第4期19-22,共4页China Modern Doctor

基　　金：浙江省医药卫生科技一般项目(2014KYB283);浙江省绍兴市卫生计生科技计划项目(2016QN008)。

摘　　要：目的观察儿童首发抑郁症患者血清维生素D与白介素-6水平的相关性,进一步探讨儿童抑郁症发病的可能病理机制。方法检测2016年1月1日~12月31日期间我院儿童精神科56例儿童抑郁症患者和52名儿童健康体检者血清维生素D和白介素-6的浓度,采用汉密尔顿抑郁量表(HAMD)评估儿童抑郁症患者的抑郁情况。并对儿童抑郁症患者血清维生素D和白介素-6与HAMD评分进行相关性分析。结果与正常人群相比,儿童抑郁症患者的血清维生素D水平偏低(t=-9.821,P<0.05),白介素-6的浓度偏高(t=7.692,P<0.05)。儿童抑郁症患者HAMD评分与血清维生素D浓度呈负相关(r=-0.629,P=0.009),与血清白介素-6浓度呈正相关(r=0.538,P=0.022);儿童抑郁症患者血清维生素D浓度与白介素-6浓度无相关(r=2.39,P>0.05)。结论儿童抑郁症患者的血清维生素D处于较低水平,有必要检测儿童抑郁症患者维生素D水平,同时及时补充维生素D;儿童抑郁症患者血清白介素-6水平与抑郁症状呈正相关,提示炎症因子可能参与儿童抑郁症的发病。Objective To observe the correlation between serum vitamin D and interleukin-6 level in children with first-episode depression,and to explore the possible pathological mechanism of children's depression.Methods The concentration of serum vitamin D and interleukin-6 in 56 children with depression and 52 children health checkup in the children's psychiatric department of our hospital from January 1,2016 to December 31,2016 were measured.The Hamilton Depression Scale(HAMD)was used to assess depression in children with depression.Correlation analysis between serum vitamin D,interleukin-6 and HAMD scores in children with depression was performed.Results Compared with that of the normal population,serum vitamin D level was lower in children with depression(t=-9.821,P<0.05),and the concentration of interleukin-6 was higher(t=7.692,P<0.05).HAMD scores in children with depression were negatively correlated with serum vitamin D concentration(r=-0.629,P=0.009),and positively correlated with serum interleukin-6 concentration(r=0.538,P=0.022).There was no correlation between serum vitamin D concentration and interleukin-6 concentration in children with depression(r=2.39,P>0.05).Conclusion Serum vitamin D level in children with depression is at a low level.It is necessary to detect vitamin D in children with depression and to add vitamin D in time.Serum interleukin-6 levels in children with depression are positively correlated with depressive symptoms,suggesting that inflammatory factors may be involved the onset of children's depression.

关 键 词：儿童首发抑郁症 维生素D 白介素-6 汉密尔顿抑郁量表 

分 类 号：R747.1[医药卫生—神经病学与精神病学]