NK细胞相关免疫检查位点的研究进展  

Progress on NK cell-related immune checkpoint

作　　者：唐家优(综述) 彭艳(审校)[2] TANG Jia-you;PENG Yan(College of Life Sciences,Guangxi Normal University,Guilin 541004,Guangxi,China;State Key Laboratory for Chemistry and Molecules Engineering of Medicinal Resources,Guangxi Normal University,Guilin 541004,Guangxi,China)

机构地区：[1]广西师范大学生命科学学院,桂林541004 [2]广西师范大学药用资源化学与药物分子工程国家重点实验室,桂林541004

出　　处：《东南国防医药》2020年第2期183-187,共5页Military Medical Journal of Southeast China

基　　金：国家自然科学基金(81673473)。

摘　　要：自然杀伤(NK)细胞是机体内重要的免疫细胞。NK细胞的多种受体(PD-1、NKG2A、TIGIT、TIM-3等)具有充当抗肿瘤免疫检查位点的潜力;通过对这些受体的活性进行激活或抑制,使NK细胞正常发挥免疫调控作用,为肿瘤的免疫治疗提供了新的研究方向。文章主要就NK细胞受体作为肿瘤免疫治疗的免疫检查位点以及检查位点相关抑制剂的研究现状进行综述。Natural killer(NK) cells are of importance immune cells in the body.Multiple receptors of NK cells(PD-1,NKG2 A,TIGIT,TIM-3,etc.) have the potential to act as anti-tumor immune checkpoint.By activating or inhibiting the activity of these receptors,NK cells can normally play their immune regulatory role,which offers a new research direction for the immunotherapy of tumors.This article mainly summarizes the advances of NK cell receptors as immune checkpoint for tumor immunotherapy and checkpoint relates inhibitors.

关 键 词：NK细胞 NK细胞受体 免疫检查位点 免疫治疗 

分 类 号：R73[医药卫生—肿瘤]