18F-FDG PET/CT在宫颈癌术后临床怀疑复发和转移病人中的应用价值  

Application value of 18F-FDG PET/CT in patients with suspected recurrence and metastasis after cervical cancer surgery

作　　者：訾刚[1] 李辉[1] 胡永全[1] 袁超[1] ZI Gang;LI Hui;HU Yong-quan;YUAN Chao(Department of Nuclear Medicine,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院核医学科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2020年第1期106-109,112,共5页Journal of Bengbu Medical College

摘　　要：目的:探讨18F-FDG PET/CT对宫颈癌术后临床怀疑复发和转移病人中的应用价值。方法:收集临床怀疑宫颈癌术后复发及转移的女性病人56例。病人均进行18F-FDG PET/CT全身显像,应用半定量分析法和目测法判断结果。结果:56例病人中,50例病人存在复发和/或转移,局部复发病灶的SUVmax从3.45至18.69,平均SUVmax为8.96。18F-FDG PET/CT诊断子宫颈癌术后复发及转移的灵敏度为98.0%,特异度为83.3%,诊断准确度为92.1%,阳性预测值为96.0%,阴性预测值为80.0%。CT分别为69.7%、78.9%、73.2%、86.7%、57.6%。两者各诊断效能指标比值比较,灵敏度、阴性预测值及诊断准确度有统计学意义(P<0.05)。18F-FDG PET/CT显像诊断与组织病理或临床随访结果的一致性有统计学意义且有较高的一致性。结论:18F-FDG PET/CT显像对于宫颈癌术后临床怀疑复发和转移有重要临床实用价值,为临床制定正确的治疗方案提供重要信息。Objective:To investigate the application value of 18F-FDG PET/CT in patients with suspected recurrence and metastasis after cervical cancer surgery.Methods:The clinical data of 56 female patients with suspected recurrence and metastasis of cervical cancer were collected.All patients were detected using 18F-FDG PET/CT whole-body imaging,and the results were determined by semi-quantitative analysis and visual examination.Results:Among 56 patients,the recurrence and/or metastasis in 50 patients were found.The SUVmax of local recurrence focus ranged from 3.45 to 18.69,with an average SUVmax of 8.96.The sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value of 18F-FDG PET/CT in the diagnosis of recurrence and metastasis of cervical cancer after operation were 98.0%,83.3%,92.1%,96.0%and 80.0%,respectively.The sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value of CT were 69.7%,78.9%,73.2%,86.7%and 57.6%,respectively.The differences of the sensitivity,negative predictive value and diagnostic accuracy between two methods were statistically significant(P<0.05).The results of 18F-FDG PET/CT imaging diagnosis were consistent with the histopathological or clinical following-up results.Conclusions:The 18F-FDG PET/CT imaging has important clinical practical value for suspected recurrence and metastasis of cervical cancer after operation,and can provide the important information for making correct treatment plan.

关 键 词：宫颈肿瘤 18F-FDG PET/CT 复发 转移 

分 类 号：R737.3[医药卫生—肿瘤] R814.42[医药卫生—临床医学]