抗疟疾药物研究进展  

Progress on Antimalarial Drugs

作　　者：吴芷静 魏子巍 李娇 鲍丽 段萍 姜宁[1] WU Zhi-jing;WEI Zi-wei;LI Jiao;BAO Li;DUAN Ping;JIANG Ning(College of Animal Husbandry and Veterinary,Medicine Shenyang Agricultural University,Shenyang,Liaoning,110866,China;Liaoning Blood Center,Shenyang,Liaoning,110866,China)

机构地区：[1]沈阳农业大学畜牧兽医学院,辽宁沈阳110866 [2]辽宁省血液中心,辽宁沈阳110866

出　　处：《动物医学进展》2020年第3期106-109,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(81772219)。

摘　　要：疟疾是由疟原虫引起的严重危害人类健康和生命安全的重要寄生虫病。近年针对产生耐药性的疟原虫虫株,亟需开发新型的抗疟药物。疟原虫入侵宿主需要蛋白质相互作用、蛋白酶裂解和肌动蛋白-肌球蛋白等关键分子的参与和协调,上述参与入侵过程的蛋白质为抗疟药物开发供了潜在靶点。论文对抗疟原虫入侵关键分子的药物做一概述。Malaria is an important parasitic infectious disease caused by Plasmodium falciparum,which seriously endangers human health and life safety.At present,it is urgent to develop new anti-malaria drugs for resistant Plasmodium falciparum strains.The invasion of Plasmodium falciparum requires the participation and coordination of key molecules such as protein interaction,protease lysis and actin-myosin.The proteins involved in the invasion process provide potential targets for the development of anticalarial drugs.In this paper,the drugs against Plasmodium falciparuminvading key molecules were summarized.

关 键 词：疟原虫 入侵 抗疟药 

分 类 号：S859.79[农业科学—临床兽医学]