泛素-蛋白酶体系统在非小细胞肺癌中作用机制的研究进展  

The potential mechanism of ubiquitin-proteasome system in non-small cell lung cancer

作　　者：王玉秀 闵凌峰 Wang Yuxiu;Min Lingfeng(Departmentof Respiratory Medicine,Northern Jiangsu People′s Hospital,Clinical Medical College of Yangzhou University,Yangzhou 225001,China)

机构地区：[1]江苏省苏北人民医院,扬州大学临床医学院呼吸内科,225001

出　　处：《国际呼吸杂志》2020年第4期297-301,共5页International Journal of Respiration

基　　金：国家自然科学基金(81302016);江苏省"六大人才高峰计划"(2015-WSN-106)。

摘　　要：泛素-蛋白酶体系统(UPS)是一个复杂的控制系统,负责降解80%~90%的蛋白质,是调节细胞功能和维持蛋白质同源性的关键。研究显示其在多种肿瘤发生、发展中有重要的作用,因此,近年来UPS的成分作为肺癌诊断以及治疗的潜在靶点引起了广泛的关注。本综述将对非小细胞肺癌中的UPS和UPS在非小细胞肺癌发生、发展中潜在的作用机制的研究现状作一综述。The ubiquitin-proteinasome system(UPS)is a complex control system responsible for the degradation of 80%-90%of proteins and is the key to regulating cellular function and maintaining protein homology.Studies have shown that it plays an important role in the development of a variety of tumors.Therefore,the component of UPS has attracted extensive attention as a potential target for the diagnosis and treatment of lung cancer in recent years.This article reviews the research status of UPS in non-small cell lung cancer and its potential mechanism in the development of non-small cell lung cancer.

关 键 词：癌 非小细胞肺 泛素-蛋白酶体系统 作用机制 

分 类 号：R734[医药卫生—肿瘤]