带角膜缘干细胞的自体结膜瓣移植术对翼状胬肉患者泪膜稳定性的影响  

Clinical analysis of dry eye and tear film stability in pterygium patients after autologous conjunctival flap transplantation

作　　者：刘青 郭佳[1] 朱思泉 Qing Liu;Jia Guo;Si-Quan Zhu(Department of Ophthalmology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院眼科,北京100029

出　　处：《国际眼科杂志》2020年第4期680-683,共4页International Eye Science

摘　　要：目的:探讨带角膜缘干细胞的自体结膜瓣移植术对翼状胬肉患者干眼及泪膜稳定性的分析。方法:选择114例138眼翼状胬肉患者,根据治疗方式不同分为传统组56例67眼,试验组58例71眼,观察两组术前、术后1、3mo的SⅠt值、BUT值、FL值以及术后两组患者眼球表面温度及干眼症评分。结果:传统组总有效率83.6%,试验组总有效率95.8%,两组有差异(χ2=5.207,P=0.022);两组术前SⅠt值无差异(P>0.05),试验组术后1、3mo SⅠt值较传统组升高更为显著(均P<0.05);传统组、试验组术前BUT值无差异(P>0.05),术后1、3mo试验组BUT值较传统组明显增加(均P<0.05);传统组、试验组术前FL分值无差异(P>0.05),试验组术后1、3mo FL值较传统组有所降低(均P<0.001);传统组、试验组眼球表面温度无差异(P>0.05),干眼症评分试验组明显低于传统组(P<0.05)。结论:采用带角膜缘干细胞的自体结膜瓣移植术疗效优于行翼状胬肉切除联合羊膜移植术,可促进翼状胬肉患者泪膜稳定性恢复,患者干眼症状有明显改善。AIM:To investigate the clinical analysis of dry eye and tear film stability in pterygium patients after autologous conjunctival flap transplantation.METHODS:Totally 114 cases of 138 eyes with pterygium were selected and divided into 56 groups of 67 eyes in the traditional group and 58 eyes of 71 eyes in the experimental group.The SⅠt values and BUT values of the two groups were observed before,1 and 3mo after the operation,FL value,eye surface temperature and dry eye score of the two groups after surgery.RESULTS:The total effective rate of the traditional group was 83.6%,and the total effective rate of the experimental group was 95.8%.The difference between the two groups was statistically significant(χ2=5.207,P=0.022);there was no difference in the SⅠt value before surgery between the two groups(P>0.05),SⅠt values in the experimental group increased significantly at 1,3mo after surgery compared with the traditional group(both P<0.05);there was no difference in BUT values before surgery in the traditional and experimental groups(P>0.05),and at 1 and 3mo after surgery the BUT value in the group was significantly increased compared with the traditional group(both P<0.05);there was no difference in the FL score between the traditional group and the experimental group before surgery(P>0.05).FL value was decreased in the experimental group campared to the traditional group 1,3mo after surgery(All P<0.05);there was no difference in eye surface temperature between the traditional group and the experimental group(P>0.05),and the dry eye score test group was significantly lower than the traditional group(P<0.05).CONCLUSION:Autologous conjunctival flap transplantation is superior to simple tendon resection,which can promote the recovery of tear film stability in patients with pterygium,and the dry eye symptoms of patients are significantly improved.

关 键 词：角膜缘干细胞 自体结膜瓣移植术 翼状胬肉:泪膜稳定性 干眼 

分 类 号：R779.6[医药卫生—眼科]