巨细胞病毒感染与新生儿连接蛋白Cx基因易感性及听力影响研究  

Correlation between cytomegalovirus infection and neonatal connexin Cx gene and its impact on hearing

作　　者：季卫刚[1] 张娟 仲越[2] 陆艺 邵骏[3] JI Wei-gang;ZHANG Juan;ZHONG Yue;LU Yi;SHAO Jun(Jiangsu Nantong Maternal and Child Health Hospital,Nantong,Jiangsu 226000,China)

机构地区：[1]南通市妇幼保健院儿科,江苏南通226000 [2]南通市妇幼保健院科教科,江苏南通226000 [3]南通市妇幼保健院检验科,江苏南通226000

出　　处：《中华医院感染学杂志》2020年第2期242-245,共4页Chinese Journal of Nosocomiology

基　　金：南通市科学技术局计划项目(MS12017013-5)。

摘　　要：目的探究巨细胞病毒感染与新生儿连接蛋白Cx基因的相关性及其对新生儿听力的影响。方法选取2017年1月-2018年4月于南通市妇幼保健院出生或就诊的新生儿为研究对象,其中发生先天性巨细胞病毒感染的86例新生儿为研究组,抽取未发生先天性巨细胞病毒感染的232例新生儿为对照组。比较两组新生儿血清总胆红素(TBiL)、谷氨酸转氨酶(ALT)以及天门冬氨酸转氨酶(AST)水平;比较两组新生儿连接蛋白Cx基因突变率及突变情况;比较两组新生儿听力随访结果以及不同程度耳聋人数占比。统计听力有问题的新生儿脑干听觉诱发电位。使用Pearson相关分析研究连接蛋白Cx基因突变与新生儿巨细胞病毒感染以及听力障碍之间的相关性。结果研究组新生儿TBiL、ALT、AST水平分别为(19.58±4.32)μmol/L、(48.76±10.43)U/L、(69.48±18.76)U/L,明显高于对照组新生儿(10.87±4.49)μmol/L、(28.77±9.35)U/L、(38.14±13.08)U/L,两组数据比较差异有统计学意义(P<0.05)。研究组新生儿连接蛋白Cx基因突变27例(31.39%),对照组新生儿连接蛋白Cx基因突变4例(1.72%),两组数据比较差异具有明显统计学意义(P<0.05)。听力随访结果比较发现,研究组新生儿未通过初筛47例(54.65%),对照组新生儿未通过初筛28例(12.06%),两组比较差异有统计学意义(P<0.05)。Pearson相关分析结果,连接蛋白Cx基因突变和新生儿发生先天性巨细胞病毒感染呈正相关关系。结论新生儿连接蛋白Cx基因突变与巨细胞病毒感染之间存在相关性,发生突变的新生儿更容易感染巨细胞病毒,且听力障碍发生率更高。OBJECTIVE To explore the correlation between cytomegalovirus infection and neonatal connexin(Cx) gene and observe its impact on neonatal hearing. METHODS The neonates who were born and treated in Jiangsu Nantong Maternal and Child Health Hospital from Jan 2017 to Apr 2018 were recruited as the study objects, 86 neonates who had congenital cytomegalovirus infection were assigned as the study group, and 232 neonates who did not have congenital cytomegalovirus infection were chosen as the control group.The levels of serum total bilirubin(TBiL), glutamate transaminase(ALT) and aspartate aminotransferase(AST) were compared between the two groups of neonates.The mutation rate of neonatal connexin Cx gene and mutation status were compared between the two groups of neonates.The brainstem auditory evoked potentials of the neonates who had hearing problems were statistically analyzed.Pearson correlation analysis was performed for the correlation between the mutation of connexin Cx gene and the neonatal cytomegalovirus infection as well as the hearing disorder. RESULTS The levels of TBiL, ALT and AST of the study group were respectively(19.58±4.32)μmol/L,(48.76±10.43)U/L and(69.48±18.76)U/L, significantly higher than(10.87±4.49)μmol/L,(28.77±9.35)U/L and(38.14±13.08)U/L of the control group(P<0.05).Totally 27(31.39%) neonates had connexin Cx gene mutation in the study group, 4(1.34%) neonates in the control group, and there was significant difference between the two groups(P<0.05).The result of the follow-up for hearing showed that totally 47(54.65%) neonates did not pass the preliminary screening in the study group, 28(12.06%) neonates in the control group, and there was significant difference between the two groups(P<0.05).The Pearson correlation analysis indicated that the mutation of neonatal connexin Cx gene was positively correlated with the congenital cytomegalovirus infection. CONCLUSION There is correlation between the mutation of neonatal connexin Cx gene and the cytomegalovirus infection, and the neonates

关 键 词：巨细胞病毒感染 新生儿 连接蛋白Cx基因 听力 

分 类 号：R373[医药卫生—病原生物学]