阿尔茨海默病患者免疫功能状态研究  

Study of immunologic function in patients with Alzheimer’s Disease

作　　者：夏伟琴 徐丽芬[2] 缪晓明 费玉娥[2] 陈爱学[2] XIA Wei-qin;XU Li-fen;MIAO Xiao-ming;FEI Yu-e;CHEN Ai-xue(Tongxiang Hospital of Traditional Chinese Medicine,Tongxiang,Zhejiang 314500,China;不详)

机构地区：[1]桐乡市中医医院,浙江桐乡314500 [2]嘉兴市康慈医院,浙江嘉兴314500

出　　处：《中国卫生检验杂志》2020年第4期451-453,456,共4页Chinese Journal of Health Laboratory Technology

基　　金：桐乡市引导性科技计划项目(201603086)。

摘　　要：目的探讨阿尔茨海默病(AD)患者的免疫功能状态。方法随机收集AD患者125例与健康对照组40例,分别检测2组对象的外周血T淋巴细胞亚群、IgA、IgG、IgM、C3、C4、白细胞介素(IL)-1β、IL-2、IL-6、干扰素(IFN)-γ等指标来评定受试者的免疫功能状态,并进行比较。结果 AD患者的血清C3浓度明显高于健康对照组(P <0. 05),AD患者的静脉血CD4^+浓度及CD4^+/CD8^+均明显高于健康对照组(P <0. 05),AD患者的静脉血CD8^+浓度明显低于健康对照组(P <0. 05),AD患者的血清IL-1β、IL-2、IL-6、IFN-γ等指标均明显高于健康对照组,上述差异均有统计学意义(P <0. 05),Logistic回归分析提示外周血C3与IL-6升高增加AD患病风险。结论 AD患者存在免疫功能状态的改变,后者在AD的发生发展中起着重要作用。Objective To explore the immunologic function in patients with Alzheimer’s disease( AD). Methods A total of125 patients with AD and 40 healthy elderly people were enrolled in this trial. The levels of their T lymphocyte subsets,IgA,IgG,IgM,C3,C4,interleukin( IL)-1β,IL-2,IL-6 and interferon( IFN)-γ in peripheral blood were tested to assess the immunologic function. Then the outcomes were compared. Results The serum C3 level in AD patients was significantly higher than that in the controls( P < 0. 05);levels of CD4^+and CD4^+/CD8^+in peripheral blood in AD patients were significantly higher than those in the controls( P < 0. 05);the CD8^+level in peripheral blood in AD patients was significantly lower than that in the controls( P < 0. 05);the serum levels of IL-1β,IL-2,IL-6,IFN-γ in AD patients were significantly higher than those in healthy individuals( P < 0. 05). The rise of serum C3 and IL-6 were independent protective factors related to AD according to the Logistic regression analysis. Conclusion Changes of immunologic function occurs in patients with AD,which plays an important role in the process of AD.

关 键 词：阿尔茨海默病 免疫功能 免疫球蛋白 T淋巴细胞亚群 细胞因子 

分 类 号：R749.16[医药卫生—神经病学与精神病学]