晚期肝癌患者化疗栓塞术疗效与血清γ-谷氨酰转肽酶水平相关性分析  

Correlation between curative effect of transcatheter arterial chemoembolization on advanced liver cancer and serumγ-glutamyl transpeptidase level

作　　者：李丹[1] 王树庚[1] 赵飞[2] Li Dan;Wang Shugeng;Zhao Fei(The Second Department of Comprehensive Medicine,the Second Hospital of Qinhuangdao,Hebei Province,Qinhuangdao 066600,China;Department of Dermatology,the Second Hospital of Qinhuangdao,Hebei Province,Qinhuangdao 066600,China)

机构地区：[1]河北省秦皇岛市第二医院综合二科,066600 [2]河北省秦皇岛市第二医院皮肤科,066600

出　　处：《中国医药》2020年第2期263-266,共4页China Medicine

基　　金：河北省医学科学研究课题计划(20191368)。

摘　　要：目的分析晚期肝癌患者经导管动脉化疗栓塞术(TACE)疗效与γ-谷氨酰转肽酶(GGT)水平的相关性。方法回顾性分析2010年2月至2016年5月河北省秦皇岛市第二医院行TACE治疗的80例晚期原发性肝癌患者的临床资料,根据TACE术前血清GGT水平分为正常GGT组(GGT<50 U/L,35例)和高GGT组(GGT≥50 U/L,45例)。采用Pearson相关性检验分析TACE疗效与GGT、甲胎蛋白(AFP)、碱性磷酸酶(AKP)水平的关系。结果高GGT组TACE治疗有效率明显低于正常GGT组[37.8%(17/45)比71.4%(25/35)],差异有统计学意义(χ^2=8.940,P=0.003)。TACE治疗有效组(42例)术前及术后28 d血清GGT[(67±7)U/L比(179±14)U/L、(35±6)U/L比(136±14)U/L]、甲胎蛋白[(158±11)μg/L比(169±11)μg/L、(87±8)μg/L比(111±10)μg/L]、AKP[(207±18)U/L比(223±19)U/L、(115±12)U/L比(144±16)U/L]水平均明显低于无效组(38例),差异均有统计学意义(均P<0.001)。Pearson相关性分析显示,血清GGT、甲胎蛋白、AKP水平与TACE疗效呈明显负相关关系(r=-0.382、-0.435、-0.561,均P<0.001)。结论晚期肝癌患者化疗栓塞术疗效与血清GGT、甲胎蛋白、AKP水平具有相关性。Objective To analyze the correlation between curative effect of transcatheter arterial chemoembolization(TACE)on advanced liver cancer and serumγ-glutamyl transpeptidase(GGT)level.Methods Clinical records of 80 patients with advanced liver cancer who underwent TACE in the Second Hospital of Qinhuangdao,Hebei Province from February 2010 to May 2016 were retrospectively analyzed.According to serum GGT level before TACE,they were divided into normal GGT group(GGT<50 U/L,35 cases)and high GGT group(GGT≥50 U/L,45 cases).Pearson correlation was performed to analyze the relation of TACE efficacy with GGT,alpha-fetoprotein(AFP)and alkaline phosphatase(AKP).Results The therapeutic response rate of TACE in high GGT group was significantly lower than that in normal GGT group[37.8%(17/45)vs 71.4%(25/35)](χ^2=8.940,P=0.003).Serum levels of GGT[(67±7)U/L vs(179±14)U/L,(35±6)U/L vs(136±14)U/L],AFP[(158±11)μg/L vs(169±11)μg/L,(87±8)μg/L vs(111±10)μg/L]and AKP[(207±18)U/L vs(223±19)U/L,(115±12)U/L vs(144±16)U/L]before and 28 d after TACE in the effective group(42 cases)were significantly lower than those in the ineffective group(38 cases)(all P<0.001).Pearson analysis showed that levels of serum GGT,AFP and AKP were negatively correlated with TACE efficacy(r=-0.382,-0.435,-0.561;P<0.05).Conclusion Serum levels of GGT,AFP and AKP are associated with the curative effect of TACE on advanced liver cancer.

关 键 词：肝肿瘤 经导管动脉化疗栓塞术 Γ-谷氨酰转肽酶 

分 类 号：R735.7[医药卫生—肿瘤]