皮肤恶性黑色素瘤患者Cx43表达水平及预后影响因素分析  

Expression level and clinical significance of Cx43 in skin malignant melanoma

作　　者：王峻岭[1] 李慧[1] 张冀北[1] 张丽 刘芳芳 WANG Junling;LI Hui;ZHANG Jibei(Department of Burn and Plastic Surgery,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院烧伤整形科,061000

出　　处：《安徽医学》2020年第2期134-137,共4页Anhui Medical Journal

基　　金：沧州市重点研发计划指导项目(项目编号:183302061)。

摘　　要：目的探讨皮肤恶性黑色素瘤患者缝隙连接蛋白43(Cx43)的表达水平及其预后影响因素。方法选取2015年1月至2016年12月河北省沧州市中心医院收治的56例皮肤恶性黑色素瘤患者为研究对象,比较患者癌组织和癌旁组织的Cx43表达水平,根据癌组织Cx43的表达水平分为高表达组和低表达组,各28例。比较两组患者的临床病理特征和生存状况,采用多因素Cox回归模型分析患者预后的影响因素。结果皮肤恶性黑色素瘤患者癌组织Cx43相对表达水平低于癌旁组织,差异有统计学意义(t=2.392,P<0.05)。低表达组原发灶-淋巴结-远处转移(TNM)分期为Ⅲ~Ⅳ期、Clark分级为Ⅴ级的比例高于高表达组,中位生存时间低于高表达组,差异均有统计学意义(χ^2=5.976、5.793、16.875,P<0.05)。癌组织Cx43低表达、TNM分期为Ⅲ~Ⅳ期、发病部位为非肢端是皮肤恶性黑色素瘤患者预后的影响因素(HR=2.156、3.156、1.896,P<0.05)。结论皮肤恶性黑色素瘤患者的癌组织Cx43表达水平明显低于癌旁组织,癌组织Cx43低表达、TNM分期晚、非肢端发病是其预后的影响因素。Objective To investigate the expression of connexin 43(Cx43)and the prognosis in patients with skin malignant melanoma.Methods Fifty-six patients with cutaneous malignant melanoma admitted to Cangzhou Central Hospital of Hebei Province from January 2015 to December 2016were enrolled in the study.The expression level of Cx43 in cancer tissues and paracancerous tissues was compared.Patients were divided into high expression group and low expression group according to the median value of the relative expression level of Cx43 in cancer tissues,with 28 cases in each group.The clinicopathological characteristics and survival status of the patients were compared between the two groups.Multivariate Cox proportional risk regression model was performed to analyze the prognostic factors of patients.Results The relative expression level of Cx43 in cancer tissues of all patients was significantly lower than that in adjacent tissues(t=2.392,P<0.05).The proportions of tumor-Node-Metastasis(TNM stage)Ⅲ-Ⅳ and Clark grade V in low-expression group were significantly higher than those in high-expression group,and the median survival time was significantly lower than that in high-expression group(χ^2=5.976,5.793,16.875,P<0.05).Low expression of Cx43 in cancer tissues,TNM stage Ⅲ-Ⅳ and non-extremity sites were the independent prognostic factors in patients with skin malignant melanoma(HR=2.156,3.156,1.896,P<0.05).Conclu sion The expression level of Cx43 in skin malignant melanoma is significantly lower than that in adjacent tissues.Compared with the high expression of Cx43 in cancer tissues,the tumor stage of patients with low expression of Cx43 in cancer tissues is laterand the tumor invasion is deeper.The low expression of Cx43 in cancer tissues is an independent risk factor for death.

关 键 词：缝隙连接蛋白43 皮肤恶性黑色素瘤 癌旁组织 预后 

分 类 号：R739.5[医药卫生—肿瘤]