颅内动脉瘤栓塞术中急性血栓栓塞经动脉灌注替罗非班溶栓治疗的效果  

Effect of intra-arterial infusion of tirofiban in the treatment of acute thromboembolism of intracranial aneurysm embolization

作　　者：杨玉超[1] 董奇观[2] 池琦[3] Yang Yuchao;Dong Qiguan;Chi Qi(Neurology Department,General Hospital of Fushun Mining Bureau,Liaoning Fushun 113000,China;Oncology Department,General Hospital of Fushun Mining Bureau,Liaoning Fushun 113000,China;Imaging Department,General Hospital of Fushun Mining Bureau,Liaoning Fushun 113000,China)

机构地区：[1]抚顺矿务局总医院神经内科,辽宁抚顺113000 [2]抚顺矿务局总医院肿瘤内科,辽宁抚顺113000 [3]抚顺矿务局总医院影像科,辽宁抚顺113000

出　　处：《现代肿瘤医学》2020年第7期1113-1115,共3页Journal of Modern Oncology

摘　　要：目的:探讨颅内动脉瘤栓塞术中急性血栓栓塞,经动脉灌注替罗非班溶栓是否有良好的效果。方法:选取抚顺矿务局总医院2015年1月至2018年8月,经CTA、MRA证实的颅内动脉瘤患者(全部选取支架辅助治疗)术中发生动脉急性血栓栓塞80例,分为替罗非班组(A组)40例,尿激酶组(B组)40例,采用介入置管溶栓方法,分别经溶栓导管动脉注入替罗非班、尿激酶,即时血管通畅,观察术后1天、1周、1个月脑出血、脑梗死并发症的发生例数。结果:术后1天、1周、1个月行CT检查,A组脑出血例数分别为3例、7例、8例,B组分别为8例、18例、25例;A、B两组差异有统计学意义(P<0.05);术后1天、1周、1个月,A组脑梗死例数分别为5例、7例、9例,B组分别为8例、14例、19例;A、B两组差异有统计学意义(P<0.05)。结论:术中应用替罗非班处理颅内动脉瘤栓塞术中急性血栓栓塞,可获得良好的效果。Objective:To investigate the effect of intra-arterial infusion of tirofiban on acute thromboembolism in intracranial aneurysms.Methods:From January 2015 to August 2018,80 patients with intracranial aneurysms confirmed by CTA and MRA were divided into tirofiban group A(40 cases) and urokinase group B(40 cases) by interventional catheterization and thrombolysis respectively.Tirofiban and urokinase were injected into the arteries of the catheter to patency the blood vessels immediately.The incidence of cerebral hemorrhage and cerebral infarction complications was observed on 1 st day,in 1 week and 1 month after operation.Results:CT examination was performed on 1 st day,in one week and one month after operation.The number of cerebral hemorrhage cases in group A was 3,7 and 8 respectively,while that in group B was 8,18 and 25 respectively.The difference between group A and B was statistically significant(P<0.05).There were 5,7,9 cases of cerebral infarction in group A,and 8,14,19 cases in group B.There was a significant difference between the two groups of A and B(P<0.05).Conclusion:Tirofiban can be used to treat acute thromboembolism during embolization of intracranial aneurysms.

关 键 词：颅内动脉瘤 动脉内灌注 替罗非班 尿激酶 

分 类 号：R739.41[医药卫生—肿瘤]