ACK1在肿瘤发生发展中的研究进展  

Research progress of ACK1 in the development of tumors

作　　者：赵梦 刘扬[2] 刘杰[1] 朱锦红[1,3] 彭士云[4] Zhao Meng;Liu Yang;Liu Jie;Zhu Jinhong;Peng Shiyun(Clinical Laboratory,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;Department of Medical Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;Biobank,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;Precision Medicine,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院检验科,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院肿瘤内科,黑龙江哈尔滨150081 [3]哈尔滨医科大学附属肿瘤医院生物样本库,黑龙江哈尔滨150081 [4]哈尔滨医科大学附属肿瘤医院精准医学,黑龙江哈尔滨150081

出　　处：《现代肿瘤医学》2020年第7期1205-1208,共4页Journal of Modern Oncology

基　　金：海燕科研基金项目(编号:JJZD2016-03)。

摘　　要：激活的cdc42相关酪氨酸激酶1(activated cdc42-associated tyrosine kinase 1,ACK1)作为一种非受体酪氨酸激酶,参与多种细胞生理活动,与许多肿瘤发生发展息息相关,在前列腺癌、乳腺癌、肺癌等多种肿瘤中均高表达,并与转移、浸润和预后等相关。本文拟就ACK1的结构特点、生物学功能及其在各种肿瘤中发挥的作用进行简要综述。As a non-receptor tyrosine kinase,activated cdc42-associated tyrosine kinase(ACK1) is involved in a variety of cell physiological activities and is also closely related to the development of many tumors.ACK1 is highly expressed in prostate cancer,breast cancer,lung cancer,and it is associated with metastasis,infiltration and prognosis.This article briefly reviews the structural features,biological functions of ACK1 and its related research progress in invasion,migration and its role in a wide variety of tumors.

关 键 词：ACK1 肿瘤 高表达 

分 类 号：R730[医药卫生—肿瘤]