蜂针疗法对肺癌合并癌性疼痛患者疼痛介质的影响  

Effect of bee acupuncture on pain mediators in lung cancer patients with cancer pain

作　　者：安香珍 张淼[2] 张燕[2] 孙毅 李国英 赵新 王培培[2] 李亚茹 段媛媛 梁欢[2] 高振林[2] 陈吉红 AN Xiang-zhen;ZHANG Miao;ZHANG Yan;SUN Yi;LI Guo-ying;ZHAO Xin;WANG Pei-pei;LI Ya-ru;DUAN Yuan-yuan;LIANG Huan;GAO Zhen-lin;CHEN Ji-hong(Department of Traditional Chinese Medicine,Shijiazhuang No.1 Hospital,Shijiazhuang,Hebei 050011,China;不详)

机构地区：[1]石家庄市第一医院中医科,河北石家庄050011 [2]石家庄市第一医院肿瘤科,河北石家庄050011

出　　处：《中国临床研究》2020年第3期398-400,404,共4页Chinese Journal of Clinical Research

基　　金：河北省中医药管理局科研计划项目(2018256)。

摘　　要：目的探讨蜂针疗法对肺癌合并癌性疼痛患者疼痛介质的影响。方法将2017年1月至2018年11月收治的86例肺癌合并癌性疼痛患者分为观察组和对照组,每组43例。对照组采用采用氨酚双氢可待因片治疗。观察组在对照组基础上,采用蜂针疗法治疗。对比两组的总有效率。采用视觉模拟评分法(VAS)评估疼痛的程度。记录患者镇痛起效时间、止痛持续时间。检测患者治疗前后血清中5羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺的水平。采用卡氏评分(KPS)评估患者的生活质量。结果观察组的总有效率比对照组高,差异有统计学意义(95.35%vs 81.40%,P<0.05)。两组治疗后的VAS评分明显降低(P<0.01);观察组治疗后的VAS评分比对照组低,差异有统计学意义(P<0.01)。两组治疗后的5-HT、NE、多巴胺明显降低(P<0.05);观察组治疗后的5-HT、NE、多巴胺比对照组低,差异有统计学意义(P<0.05)。观察组的镇痛起效时间比对照组短,止痛持续时间比对照组长,差异有统计学意义(P<0.01)。观察组的生活质量优于对照组,差异有统计学意义(P<0.05)。结论蜂针疗法可提高肺癌合并癌性疼痛的疗效,降低患者疼痛介质的释放,提高镇痛效果。Objective To investigate the effect of bee acupuncture on pain mediators in lung cancer patients with cancer pain.Methods A total of 86 patients with lung cancer and cancer pain who received treatment from January 2017 to November 2018 were divided into observation group and control group(n=43,each).The control group was treated with paracetamol dihydrocodeine tablets.The observation group was treated with bee acupuncture on the basis of the control group.The total effective rate of the two groups was compared.Visual analogue scale(VAS) was used to evaluate the degree of pain.The onset time and duration of analgesia were recorded.The levels of 5-hydroxytryptamine(5-HT),noradrenaline(NE) and dopamine in serum were measured before and after treatment.The patients′ quality of life was evaluated by Kamofsky Performance Status(KPS).Results The total effective rate of the observation group was significanlty higher than that of the control group(95.35% vs 81.40%,P<0.05).The VAS,5-HT,NE and dopamine were significant decreased after treatment in both group(all P<0.05),and the VAS,5-HT,NE and dopamine of the observation group were lower than that of the control group after the treatment(all P<0.05).The onset time of analgesia in the observation group was significantly later than that in the control group,and the duration of analgesia was significantly longer than that in the control group(all P<0.05).The quality of life in the observation group was better than that in the control group(P<0.05).Conclusion Bee acupuncture can improve the effect of lung cancer combined with cancer pain,reduce the release of pain media,and improve the analgesic effect.

关 键 词：蜂针疗法 肺癌 癌性疼痛 疼痛介质 

分 类 号：R730[医药卫生—肿瘤] R246[医药卫生—临床医学]