CA72-4联合AFP、CEA、CA19-9检测在胃肠道疾病中的临床应用价值研究  

The value of tumor markers CA72-4,AFP,CEA and CA19-9 in the diagnosis of Gastrointestinal disease

作　　者：林胜[1] 郭琴 王华国[1] 张宏伟[2] 王杨梅 LIN Sheng;GUO Qin;WANG Huaguo;ZHANG Hongwei;WANG Yangmei(Department of Clinical Laboratory,the First People′s Hospital of Ziyang,Ziyang,Sichuan 641300,China;Department of Oncology,the First People′s Hospital of Ziyang,Ziyang,Sichuan 641300,China;Department of Digestive,the First People′s Hospital of Ziyang,Ziyang,Sichuan 641300,China)

机构地区：[1]资阳市第一人民医院检验科,四川资阳641300 [2]资阳市第一人民医院肿瘤科,四川资阳641300 [3]资阳市第一人民医院消化科,四川资阳641300

出　　处：《国际检验医学杂志》2020年第7期807-811,共5页International Journal of Laboratory Medicine

基　　金：资阳市科技支撑计划(Zykjjsc20-2016-14)。

摘　　要：目的探讨糖类抗原72-4(CA72-4)联合甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)检测在胃肠道良、恶性疾病中的临床价值。方法收集2017-2018年该院就诊的胃癌(55例)、胃肠道其他癌(71例)、胃肠道良性疾病(556例)患者的临床资料与血清AFP、CEA、CA72-4、CA19-9检查结果,分析肿瘤标志物在不同疾病组间的表达差异。结果(1)血清CA72-4水平在胃癌组与良性疾病组、胃癌组与其他癌组比较,差异有统计学意义(P<0.05)。血清CA72-4在胃癌组的阳性率(30.91%)明显高于其他癌组(18.84%)及良性疾病组(17.99%)。(2)血清CA72-4在胃溃疡、胃息肉、慢性胃炎、急性胃肠炎、十二指肠溃疡、肠息肉等良性疾病的阳性率分别为15.00%、19.12%、11.02%、25.53%、24.07%、19.58%,各组间CA72-4水平及阳性率比较差异无统计学意义(P>0.05);(3)CEA单项检测用于胃癌诊断的灵敏度为23.64%,CA72-4+CEA+CA19-9联合检测用于胃癌诊断的灵敏度为47.27%;CA19-9单项检测用于胃肠道其他癌诊断的灵敏度为24.64%,AFP+CEA+CA19-9联合检测用于胃肠道其他癌诊断的灵敏度为66.20%,差异有统计学意义(P<0.05)。结论血清CA72-4联合CEA、CA19-9检测,可更好地识别胃癌;血清AFP联合CEA、CA19-9检测,可更好地识别胃肠道其他恶性肿瘤。Objective To investigate the clinical value of carbohydrate antigen 72-4(CA72-4),alpha fetoprotein(AFP),carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)in benign and malignant gastrointestinal diseases.Methods Patients with gastric cancer(55 cases),other gastrointestinal cancers(71 cases),and benign gastrointestinal diseases(556 cases)were involved in this study.Their clinical data and serum tumor marker results of AFP,CEA,CA72-4,CA19-9 were analyzed.Results(1)The serum CA72-4 level was significantly different in the gastric cancer group and the benign disease group,and the gastric cancer group and other cancer groups(P<0.05).The positive rate of serum CA72-4 in the gastric cancer group(30.91%)was significantly higher than other cancer groups(18.84%)and benign disease groups(17.99%).(2)The positive rates of serum CA72-4 in benign diseases such as gastric ulcer,gastric polyps,chronic gastritis,acute gastroenteritis,duodenal ulcer and intestinal polyps were 15.00%,19.12%,11.02%,25.53%,24.07%,19.58%respectively.There was no significant difference in CA72-4 level and positive rate among the groups(P>0.05);(3)The sensitivity of single CEA test for gastric cancer diagnosis was 23.64%,and that of CA72-4+CEA+CA19-9 combined test for gastric cancer diagnosis was 47.27%.The sensitivity of single test of CA19-9 for the diagnosis of other gastrointestinal cancers was 24.64%,and the sensitivity of AFP+CEA+CA19-9 combined test for the diagnosis of other gastrointestinal cancers was 66.20%,with statistically significant differences(P<0.05).Conclusion Serum CA72-4 combined with CEA,CA19-9,can significantly improve the detection rate of gastric cancer.Serum AFP combined with CEA,CA19-9,can significantly improve the detection rate of other gastrointestinal cancers.

关 键 词：胃肠道疾病 糖类抗原72-4 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]