AD和MCI患者梨状皮层功能连接破坏——初步分析  

Functional connectivity of the piriform is disrupted in AD and MCI:A preliminary analysis

作　　者：Megha M.Vasavada 张汉 Robert McHugh 王建利 庞冉[5] Paul J.Eslinger Prasanna Karunanayaka 杨庆宪 Megha MVasavada;Zhang Han;Robert McHugh;Wang Jian-li;Pang Ran;Paul JEslinger;Prasanna Karunanayaka;Yang Qing-xian(Department of Radiology,Pennsylvania State University College of Medicine;Department of Neurology,Pennsylvania State University College of Medicine;Department of Neural&Behavioral Sciences,Pennsylvania State University College of Medicine;Department of Neurosurgery,Pennsylvania State University College of Medicine;Department of Acupuncture,Dongfang Hospital,Beijing University of Chinese Medicine)

机构地区：[1]美国宾夕法尼亚州立大学医学院放射科 [2]美国宾夕法尼亚州立大学医学院神经内科 [3]美国宾夕法尼亚州立大学医学院神经与行为科学研究室 [4]美国宾夕法尼亚州立大学医学院神经外科 [5]北京中医药大学东方医院针灸科

出　　处：《阿尔茨海默病及相关病杂志》2020年第1期17-24,共8页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：领导家庭基金会阿尔茨海默病研究实验室和美国国立卫生研究院(NIH)研究项目资助计划(R01)(AG027771)。

摘　　要：目的:阿尔茨海默病(Alzheimer’s disease,AD)和轻度认知障碍(mild cognitive impairment,MCI)均存在嗅觉障碍,此点已经由病理学研究结果所证实。探索AD和MCI患者的嗅觉网络改变,并假设与正常人对比,患者的网络连接减低。方法:我们搜集21例MCI和15例AD患者作为研究对象,全体被试均完成嗅觉功能磁共振成像(fMRI)及梨状皮层功能连接(functional connectivity,FC)分析。结果:与对照组相比,所有患者在双侧梨状皮层与其他嗅觉相关脑区的连接均减低(ANOVA,P<0.001)。结论:嗅觉网络与情感处理相关,嗅觉网络的连接中断,是造成AD和MCI患者左侧偏侧化功能障碍的潜在原因。本研究结果提示嗅觉系统可作为AD诊断性生物标志物,并为其常见并发症(包括冷漠和快感缺失)提供证据。Purpose:Olfactory deficits,present in Alzheimer’s disease(AD)and mild cognitive impairment(MCI),coincide with the earliest presence of AD pathology.Therefore,we examined the olfactory network and hypothesized a decrease in connectivity of the olfactory network in AD and MCI patients.Methods 27 control,21 MCI,and 15 AD subjects completed olfactory functional MRI to investigate the functional connectivity(FC)of the piriform.Results Bilateral piriform showed decreased connectivity to regions involved in olfaction in patient groups compared to controls(ANOVA,P<0.001).Conclusion The olfactory network,which include regions also involved in emotion processing,is disconnected in AD and MCI patients with potential lateralization of dysfunction to the left side.This disconnection suggests the potential of the olfactory system as a diagnostic biomarker and may provide possible explanation for the high comorbidity of apathy and anhedonia in AD.

关 键 词：阿尔茨海默病 轻度认知障碍 功能磁共振成像 脑功能连接 梨状皮层 

分 类 号：R749.16[医药卫生—神经病学与精神病学]