Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment  

作　　者：TIAN Ai-ping YIN Yu-kun YU Lei YANG Bo-yan LI Ning LI Jian-ying BIAN Zhi-min HU Shang-ying WENG Chun-xiao FENG Li 

机构地区：[1]Department of Traditional Chinese Medicine,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing(100021),China [2]Department of Comprehensive Therapy,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing(100021),China [3]Department of Cancer Epidemiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing(100021),China [4]Beijing Chiamery Medical Sciences Institute,Beijing(100080),China

出　　处：《Chinese Journal of Integrative Medicine》2020年第4期263-269,共7页中国结合医学杂志（英文版）

基　　金：Supoorted by the Fund for Beijing Scienee&Technology Development of TCM(No.JJ2015-65)。

摘　　要：Objective:To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine(CM)formula could improve the efficacy of intrapleural administration of interleukin?2(IL-2)in treatment of malignant pleural effusion(MPE).Methods:A total of 110 eligible participants were randomized into the low-frequency sonophoresis(LFS)of CM(LSF/CM)group(55 cases)and the control group(55 cases)by simple randomization using a random number table.The control group was treated with an intrapleural administration of IL-2;and the LFS/CM group was treated with LFS of a CM gel formulation,combined with the same IL-2 injection as in the control group.The CM formula consisted of Semen Lepidii,Semen Sinapis,Flamulus Cinnamomi,Poriacocos,Herba Lycopi,and Radix Paeoniae Rubra.After 2-week treatment,the therapeutic outcome was determined by the change of the amount of MPE,which was evaluated by B-scan ultrasound and/or chest X-ray,and the change of quality of life(QOL)scores,which were evaluated by the Eastern Cooperative Oncology Group(ECOG)performance status.Results:A significantly higher objective remission rate(ORR)was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone(P=0.049).In addition,more patients in the LFS/CM group than in the control group had an improved QOL score(P=0.048),and no patients in the LFS/CM group had a reduced QOL.Conclusion:LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.

关 键 词：MALIGNANT PLEURAL EFFUSION LOW-FREQUENCY ultrasonic penetration Chinese medicine RANDOMIZED con trolled trial 

分 类 号：R730.5[医药卫生—肿瘤]