生物钟与非酒精性脂肪性肝病  

Circadian clock and non-alcoholic fatty liver disease

作　　者：林燕君 林苏[1] 吴奕隆 朱月永[1] Lin Yanjun;Lin Su;Wu Yilong;Zhu Yueyong(The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院肝病中心,福州350005

出　　处：《中华肝脏病杂志》2020年第3期284-288,共5页Chinese Journal of Hepatology

基　　金：福建省医学创新项目(2016-cx-033);福建自然科学基金项目(2017J01187,016Y0040)。

摘　　要：生物钟是自我维持生理和行为节律的发生器,可受外界环境因素所导引,从而同步生物行为与外界环境变化。现代的生活方式迫使人体不能同步外部时间与昼夜节律,形成社会时差。非酒精性脂肪性肝病(NAFLD)是与代谢异常密切相关的疾病。生物钟和代谢异常与NAFLD密切相关,喂养模式、喂养成分、睡眠时间、肠道菌群等改变可能参与其中。与生物钟有关的分子有望成为治疗NAFLD的潜在药物。现主要综述近年来生物钟与NAFLD的相关研究进展。The circadian clock is a generator of self-sustaining physiological and behavioral rhythms,which can be guided by external environmental factors,so as to synchronize biological behaviors with external environmental changes.The modern lifestyles make the human body incapable of synchronization to the external time with the circadian rhythm,and thus form a social jet lag.Non-alcoholic fatty liver disease(NAFLD)is a disorder closely related to metabolic abnormalities.The circadian clock is closely related to metabolic abnormalities and NAFLD and changes among them may be involved with feeding mode and ingredients,sleeping time,and intestinal flora.Molecules associated with the circadian clock are expected to become potential drugs for the treatment of NAFLD.This article mainly reviews the latest research progress of circadian clock and NAFLD.

关 键 词：生物钟 昼夜节律 非酒精性脂肪性肝病 肠道菌群 

分 类 号：R575.5[医药卫生—消化系统]