鼻咽癌新病理分型对鼻咽癌放射敏感性及预后的影响  

The radiation sensitivity and prognosissignificance of the new pathological typing of nasopharyngeal cancer

作　　者：李晓惠 许啸 徐冰清[2] 周思朗 夏云飞[3] LI Xiao-hui;XU Xiao;XU Bing-qing;ZHOU Si-lang;XIA Yun-fei(Department of Oncology,the 74th Army Hospital,Guangzhou 510318,Guangdong,China)

机构地区：[1]中国人民解放军陆军第七十四集团军医院肿瘤科,广东广州510318 [2]宜昌市中心人民医院肿瘤科,湖北宜昌443003 [3]中山大学肿瘤防治中心放疗科,广东广州510060

出　　处：《广东医学》2020年第5期454-458,共5页Guangdong Medical Journal

基　　金：国家高技术研究发展计划(863计划)(2006AA02Z4B4);广东省医学科研基金资助项目(A2018552)。

摘　　要：目的探讨61例鼻咽癌患者新的病理分型与鼻咽癌放射敏感性及预后之间的关系,评估其临床意义。方法依据鼻咽癌新病理分型标准对61例鼻咽癌患者进行新的病理分型,分析上皮型、肉瘤型、混合型三种不同病理分型对鼻咽癌患者总生存率的影响,及不同病理分型的放射敏感性。结果(1)61例鼻咽癌患者新病理分型,上皮型(epithelial carcinoma,EC)患者共43例,5年总生存率(overall survival rate,OS)79.1%;混合型(mixed sarcomatoid-epithelial carcinoma,MSEC)患者共10例,5年OS为70%;肉瘤型(sarcomatoid carcinoma,SC)共8例,5年OS为37.5%;差异有统计学意义(P=0.007)。(2)新病理分型中放射敏感病例上皮型35例(81.4%),混合型7例(70%),肉瘤型3例(37.5%),三组比较,差异有统计学意义(χ^2=6.805,P=0.033)。结论鼻咽癌新的病理分型较WHO病理分型能更好地预测患者预后,为评估鼻咽癌患者预后提供了简单实用的方法。Objective To investigate the radiation sensitivity and prognosis significance of the new pathological typing of nasopharyngeal carcinoma(NPC).Methods The correlation between the new pathological typing and radiation sensitivity was study in patients;So was the correlation between the prognostic significance and the new pathological typing.Results The patients with Type EC had significantly better OS compared with those with Type MSEC and SC.The radiation sensitivity of Type EC was significantly better than the other two types.Conclusion The new pathological typing may therefore provide a simple method to evaluate the prognosis of nasopharyngeal cancer.

关 键 词：鼻咽癌 病理分型 放射敏感性 预后 

分 类 号：R739.63[医药卫生—肿瘤] R730.55[医药卫生—临床医学]