亚低温联合脑苷肌肽治疗新生儿窒息脑损伤的临床效果及对血NO的影响  

Clinical effect of mild hypothermia combined with cattle encephalon glycoside and ignotin in the treatment of neonatal asphyxia brain injury and the influence on blood NO

作　　者：穆艳顺[1] 刘伟娟[1] 高嘉陵 刘红伟[1] 樊青曼 MU Yanshun;LIU Weijuan;GAO Jialing;LIU Hongwei;FAN Qingman(Department of Pediatrics,Huabei Petroleum General Hospital,Hebei Province,Renqiu062552,China)

机构地区：[1]华北石油管理局总医院儿科,河北任丘062552

出　　处：《中国医药导报》2020年第9期99-102,共4页China Medical Herald

基　　金：河北省医学科学研究课题计划项目(20191172)。

摘　　要：目的探讨亚低温联合脑苷肌肽治疗新生儿窒息脑损伤的临床效果及对血NO的影响。方法回顾性分析2018年5月~2019年10月华北石油管理局总医院儿科收治的新生儿窒息后中重度脑损伤患儿62例。根据治疗方法不同,将其分为亚低温联合脑苷肌肽治疗组(31例)和常规治疗组(31例)。常规治疗组给予对症支持治疗如维持电解质平衡、降颅压、抗感染、静脉营养支持等。亚低温联合脑苷肌肽治疗组在常规治疗基础上加用亚低温联合脑苷肌肽治疗。比较两组治疗后7、14 d的新生儿行为神经量表(NBNA)的变化,同时监测两组患儿血NO的动态变化。结果治疗前两组NBNA评分比较,差异无统计学意义(P>0.05)。治疗后7、14 d,两组NBNA评分高于治疗前,且亚低温联合脑苷肌肽治疗组高于常规治疗组,差异均有统计学意义(均P<0.05)。治疗前两组血NO水平比较,差异无统计学意义(P>0.05)。治疗后3、7 d,两组血NO水平低于治疗前,且亚低温联合脑苷肌肽治疗组低于常规治疗组,差异均有统计学意义(均P<0.05)。结论对新生儿窒息后脑损伤患儿采用亚低温联合脑苷肌肽治疗,可明显改善新生儿窒息后损伤患儿的NBNA评分,血NO检测有助于窒息后脑损伤的疗效判断。Objective To investigate the clinical efficacy of mild hypothermia combined with cattle encephalon glycoside and ignotin in the treatment of neonatal asphyxia brain injury and its effect on blood NO.Methods A retrospective analysis of 62 neonates with moderate and severe asphyxia brain injury who admitted to Department of Pediatrics,Huabei Petroleum General Hospital from May 2018 to October 2019.According to the different treatment methods,they were divided into mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group(31 cases)and the routine treatment group(31 cases).Symptomatic supportive treatment such as maintaining electrolyte balance,lowering intracranial pressure,anti-infection and nutritional support was given to children in routine treatment group.The children in mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group were treated with mild hypothermia combined with cattle encephalon glycoside and ignotin on the basis of conventional treatment.The changes of neonatal behavioral neuropathy assessment(NBNA)were compared between two groups on 7,14 d after treatment,and the dynamic changes of blood NO were monitored.Results There was no significant difference in NBNA score between two groups before treatment(P>0.05).NBNA scores on 7,14 d after treatment of two groups were higher than those before treatment,and mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group was higher than routine treatment group,with statistically significant differences(all P<0.05).There was no statistically significant difference in blood NO level between two groups before treatment(P>0.05).Blood NO level on 7,14 d after treatment of two groups were lower than those before treatment,and mild hypothermia combined with cattle encephalon glycoside and ignotin treatment group was lower than routine treatment group,with statistically significant differences(all P<0.05).Conclusion Mild hypothermia combined with cattle encephalon glycoside and ign

关 键 词：窒息 脑损伤 一氧化氮 脑苷肌肽 亚低温 

分 类 号：R742[医药卫生—神经病学与精神病学]