内球后穴注射大剂量鱼腥草治疗单纯疱疹病毒性角膜炎的临床观察  

Clinical observation for point-injection at the back of internal sphere of high-dose Houttuyniae Herba in the treatment of herpes simplex keratitis

作　　者：张光红 罗继红[1,2] 李杜军 杨昌友[3] 吴琳 ZHANG Guanghong;LUO Jihong;LI Dujun;YANG Changyou;WU Lin(Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan430061,China;Department of Ophthalmology,Hubei Province Academy of Traditional Chinese Medicine,Hubei Province,Wuhan430074,China;Department of Public Health,Central China Normal University Hospital,Hubei Province,Wuhan430079,China;Department of Ophthalmology,Central China Normal University Hospital,Hubei Province,Wuhan430079,China)

机构地区：[1]湖北省中医院眼科,湖北武汉430061 [2]湖北省中医药研究院眼科,湖北武汉430074 [3]华中师范大学医院公共卫生科,湖北武汉430079 [4]华中师范大学医院眼科,湖北武汉430079

出　　处：《中国医药导报》2020年第9期103-106,110,共5页China Medical Herald

基　　金：湖北省教育厅科研计划项目(D20121609);湖北省中医院五专建设项目(鄂中医院字[2018]64号)。

摘　　要：目的探讨内球后穴注射大剂量鱼腥草治疗单纯疱疹病毒性角膜炎(HSK)的临床效果及安全性。方法采用前瞻性、随机、对照、单盲的研究方法,选取2016年10月~2017年9月于湖北省中医院眼科门诊确诊的HSK患者120例(123眼),按照随机信封法分为两组,对照组60例(61眼),试验组60例(62眼)。对照组使用更昔洛韦滴眼液及更昔洛韦眼用凝胶点眼局部治疗,试验组在对照组治疗的基础上加用内球后穴穴位注射大剂量鱼腥草,15 d为1个疗程。比较两组的临床显效率、眼部症状和体征总评分,以及角膜知觉恢复情况,并随访1年比较复发率。结果治疗后,试验组的临床总显效率高于对照组,差异有高度统计学意义(P<0.01)。治疗后,两组眼部症状和体征总评分均较治疗前明显降低(P<0.01),且试验组降低较对照组显著(P<0.01)。治疗后,两组的角膜知觉均较治疗前明显恢复(P<0.01),且试验组角膜知觉恢复较对照组显著(P<0.01)。试验组的HSK复发率明显低于对照组,差异有统计学意义(P<0.05)。两组均未见明显的用药不适感及副作用。结论内球后穴注射大剂量鱼腥草结合药物与穴位刺激的双重功效,对治疗HSK的效果显著,可明显改善患者的眼部症状和体征,同时减少复发,不良反应轻微,临床上值得应用。Objective To investigate clinical efficacy and safety of point-injection at the back of internal sphere of high-dose Houttuyniae Herba in the treatment of herpes simplex keratitis(HSK).Methods A prospective,randomized,controlled,single-blind study was conducted from October 2016 to September 2017 in Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine.120 patients(123 eyes)diagnosed with HSK were selected and divided into two groups according to the random envelope method,60 patients(61 eyes)in control group and 60 patients(62 eyes)in experimental group.Control group was treated with Ganciclovir Eye Drops and Ganciclovir Eye Gel,while experimental group was added with point-injection of high-dose Houttuyniae Herba.All patients were treated for 15 days.Clinical efficacy,total scores of ocular symptoms and signs,the recovery of corneal sensitivity were compared,and the recurrence rate was compared with the follow-up for one year.Results After treatment,total clinical effective rate of experimental group was higher than that of control group,the difference was highly statistically significant(P<0.01).After treatment,total score of ocular symptoms and signs in two groups was significantly lower than that before treatment(P<0.01),and that in experimental group was significantly lower than that in control group(P<0.01).After treatment,the corneal perception of two groups recovered significantly(P<0.01),and corneal perception of experimental group recovered significantly(P<0.01).The recurrence rate of HSK in experimental group was significantly lower than that in control group(P<0.05).There was no obvious discomfort and side effects in both groups.Conclusion The double effects of Houttuyniae Herba combined with medicine and acupoint stimulation at the back of internal sphere in the treatment of HSK is significant.It can obviously improve the ocular symptoms and signs of patients,at the same time,reduce the recurrence,and the adverse reactions are slight.It is worthy of clinical applicati

关 键 词：鱼腥草 球后穴 穴位注射 单纯疱疹病毒性角膜炎 

分 类 号：R772.21[医药卫生—眼科]