Musashi-2/Ki-67双染在预测宫颈高度上皮内病变中的价值  

The value of Musashi-2/Ki-67 dual-staining in predicting high grade cervical intraepithelial lesions

作　　者：周星[1] 陈雪[1] 崔磊 孙吉瑞 张丙信[1] 李艺萱 张金库[1] ZHOU Xing;CHEN Xue;CUI Lei;SUN Ji-rui;ZHANG Bing-xin;LI Yi-xuan;ZHANG Jin-ku(Department of Pathology,Baoding First Central Hospital;Department of Cardiology,Baoding Second Hospital,Baoding 071000,Hebei,China)

机构地区：[1]保定市第一中心医院病理科 [2]保定市第二医院心内科,河北保定071000

出　　处：《川北医学院学报》2020年第1期23-25,共3页Journal of North Sichuan Medical College

基　　金：河北省医学科学研究重点课题(20181490)。

摘　　要：目的:探讨Musashi-2/Ki-67双染在宫颈癌细胞学筛查工作的临床应用价值。方法:选取277例行宫颈脱落细胞学检查的患者,采用免疫组化方法对细胞学制片行Musashi-2/Ki-67双染,统计Musashi-2/Ki-67双染在各级别宫颈病变中的表达差异,及双染辅助细胞学结果与组织学诊断的符合率。结果:Musashi-2/Ki-67双染辅助细胞学诊断结果的灵敏性高于单独使用细胞学筛查诊断结果(P<0.05);但两者特异性比较,差异无统计学意义(P>0.05);随着病变程度增加,双染阳性率也随之增加。结论:Musashi-2/Ki-67双染阳性可提示高度上皮内病变的存在,可能成为辅助宫颈细胞学筛查的新指标。Objective:To explore the clinical value of Musashi-2/Ki-67 dual-staining in cervical cancer screening.Methods:A total of 277 patients with cervical exfoliation cytology examination were selected.Immunohistochemical method was used to perform dual-staining of Musashi 2/Ki-67 on cytology sections,and the coincidence rate between the results of Musashi-2/Ki-67 dual-staining and the results of histologic diagnosis was analysized.Results:The sensitivity of Musashi-2/Ki-67 dual-staining assisted cytology was higher than that of cytology alone(P<0.05),but there was no significant difference in their specificity(P>0.05),and the positive rate increased with the degree of lesion.Conclusion:The positive rate of Musashi-2/Ki-67 dual-staining may indicate the existence of high intraepithelial lesions and may be a new index to assist cervical cytology screening.

关 键 词：Musashi-2/Ki-67双染 宫颈癌 筛查 液基细胞学 

分 类 号：R737.33[医药卫生—肿瘤]