岭南地区慢性非萎缩性胃炎证治规律的文献分析  

Literature Study on Distribution Features of Traditional Chinese Medicine Syndromes and Formula Composition Principles for Chronic Non-atrophic Gastritis in Lingnan Area

作　　者：黄远程 朱朝阳 林煜翔 梁怀枫 廖柳 蒋凯林 黄超原 刘凤斌[2] HUANG Yuan-Cheng;ZHU Chao-Yang;LIN Yu-Xiang;LIANG Huai-Feng;LIAO Liu;JIANG Kai-Lin;HUANG Chao-Yuan;LIU Feng-Bin(The First Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510006 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2020年第4期770-776,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81774264);国家中医药管理局区域中医(专科)诊疗中心建设与培育项目(国中医药医政函[2018]205号);广州中医药大学一流学科重点项目[2018(6)号]。

摘　　要：【目的】基于数据挖掘探讨岭南地区慢性非萎缩性胃炎(chronic non-atrophy gastritis,CNAG)的证候证素分布规律及用药规律。【方法】检索中国生物医学数据库、中国知网、万方数据库和维普数据库,纳入有关岭南地区CNAG的中医临床研究类文献。收集文献的一般资料、病例辨证分型、处方用药,分析其证候证素分布规律;应用中医传承辅助平台(V2.5)进行描述性统计、关联规则分析、复杂系统熵聚类分析等方法分析核心用药及组方规律。【结果】共纳入文献130篇,涉及证候类研究12篇,涉及用药类研究127篇。岭南地区CNAG常见证候类型依次为肝胃不和证、脾胃湿热证、脾胃气虚证、肝郁脾虚证、脾胃阳虚证。常见病性类证素依次为:气滞、热、气虚、湿、阳虚、阴虚。常见病位依次为胃、脾、肝。所涉及的127个中药处方共包含中药138味,以补气药、理气药、祛湿药、清热药、活血药为主。经关联规则分析,在支持度分别为10%、15%、20%,置信度为0.6的条件下,岭南地区CNAG中药处方的核心用药组合分别为211、63、25个,药物间关联规则分别为362、80、35条。复杂系统熵聚类分析及改进的互信息法分析结果显示,共得到18个核心用药组合、9首新方。【结论】岭南地区CNAG为虚实夹杂证,以实证为主,肝胃不和证、脾胃湿热证、脾胃气虚证为其核心证候,病位在胃,与脾、肝密切相关,气滞、热、气虚、湿是其基本证素;岭南地区CNAG治疗采用以益气健脾、疏肝和胃、理气燥湿法为主,辅以清热燥湿、活血行气等疗法,以陈夏六君子汤合四逆散为主方加减。Objective Data mining method was used to explore the distribution features of traditional Chinese medicine(TCM) syndrome elements and formula composition principles for chronic non-atrophic gastritis(CNAG)in Lingnan area. Methods By searching the Chinese Biomedical database,CNKI,Wanfang database and VIP database, we retrieved the clinical trials of CNAG in Lingnan area treated by TCM. The general information, syndrome differentiation, TCM prescriptions and medication in the trials were collected for investigating the distribution of syndrome elements. Descriptive statistics,association rules algorithm and complex system entropy clustering were performed in the Traditional Chinese Medicine Inheritance Support Platform System(V2.5)to analyze the core herbs and formula composition principles for CNAG. Results A total of 130 articles were enrolled into the analysis. Of the 130 articles,12 articles were about TCM syndrome study,and the other 127 were about the treatment with Chinese medicine. The frequently-seen syndromes of CNAG in Lingnan area were disharmony between liver and stomach,damp-heat in spleen and stomach,spleen and stomach qi deficiency,stagnation of liver qi and spleen deficiency, and spleen and stomach yang deficiency. The frequently-seen syndrome elements were qi stagnation,heat,qi deficiency,dampness,yang deficiency,and yin deficiency.CNAG usually affected the stomach,spleen and liver. The 127 herbal prescriptions involved 138 herbs,which could be mainly classified into the categories of herbs for supplementing qi,herbs for regulating qi,herbs for expelling dampness,herbs for clearing heat,and herbs for activating blood. The association rule analysis results showed that under the condition of supporting degree being 10%,15%,20% and confidence degree being 0.6,the amount of core drug combinations were 211,63 and 25, and the amount of inter-drug association rules were362, 80 and 35, respectively. A total of 18 core herbal combinations and 9 new candidate prescriptions were obtained after the analysis o

关 键 词：慢性非萎缩性胃炎 岭南地区 肝胃不和 脾胃湿热 脾胃气虚 益气健脾 疏肝和胃 理气燥湿 陈夏六君子汤 四逆散 

分 类 号：R573.3[医药卫生—消化系统]