调强放疗联合替莫唑胺化疗治疗脑胶质瘤术后患者的效果  

Effects of intensity-modulated radiotherapy combined with temozolomide chemotherapy in the treatment of postoperative patients with glioma

作　　者：戚进聪 徐力[1] 苏瑞林[1] QI Jincong;XU Li;SU Ruilin(Second Department of Neurosurgery,Zhanjiang Central People's Hospital,Guangdong,Zhanjiang 524045,China)

机构地区：[1]广东省湛江中心人民医院神经外二科,广东湛江524045

出　　处：《中国医药科学》2020年第2期210-212,共3页China Medicine And Pharmacy

摘　　要：目的探讨脑胶质瘤术后患者实施调强放疗联合替莫唑胺治疗的效果及对消化道症状、骨髓抑制发生率的影响。方法选取湛江中心人民医院神经外科2016年8月~2018年1月收治的100例脑胶质瘤手术患者按术后实际治疗方法分组:放疗组(n=50,调强放疗)、放化疗组(n=50,调强放疗联合替莫唑胺化疗),分析两组治疗方法的疗效、安全性及预后情况。结果放化疗组在术后3个月总有效率、术后1年无疾病进展生存率及总生存率均高于放疗组,差异有统计学意义(P<0.05)。放化疗组Ⅰ~Ⅱ度及Ⅲ~Ⅳ度不良反应发生率与放疗组组间比较,差异无统计学意义(P>0.05)。结论脑胶质瘤术后患者实施调强放疗联合替莫唑胺化疗治疗可提升疗效,改善预后,且不增加不良反应风险。Objective To investigate the effects of intensity-modulated radiotherapy combined with temozolomide in the treatment of postoperative patients with glioma and its influence on the incidence of gastrointestinal symptoms and myelosuppression.Methods 100 patients with glioma who underwent neurosurgery inthe Department of Neurosurgery of Zhanjiang Central People's Hospital from August 2016 to January 2018 were selected.According to the actual postoperative treatment method,patients were divided into radiotherapy group(n=50,intensity-modulated radiotherapy)and radiochemotherapy group(n=50,intensity-modulated radiotherapy combined with temozolomide chemotherapy).The efficacy,safety and prognosis of the two treatment methods were analyzed.Results The total effective rate at 3 months after surgery,the disease-free survival rate at 1 year after surgery and the overall survival rate in the radiochemotherapy group were higher than those in the radiotherapy group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of Grade Ⅰ-Ⅱ and Ⅲ-Ⅳ adverse reactions between the radiochemotherapy group and the radiotherapy group(P>0.05).Conclusion Intensity-modulated radiotherapy combined with temozolomide chemotherapy in the treatment of postoperative patients with glioma can improve the efficacy and prognosis without increasing the risk of adverse reactions.

关 键 词：脑胶质瘤 调强放疗 替莫唑胺 骨髓抑制 

分 类 号：R739.41[医药卫生—肿瘤]