啶氧菌酯对斑马鱼的安全性评价及其生物富集行为研究  

Study on the Biotoxicity and Bioaccumulation of Picoxystrobin in Brachydanio rerio

作　　者：郭宝元 张洋[1] 王松雪 Guo Baoyuan;Zhang Yang;Wang Songxue(Academy of National Food and Strategic Reserves Administration,Beijing 100037,China;Key Laboratory of Environmental Biotechnology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China)

机构地区：[1]国家粮食和物质储备局科学研究院,北京100037 [2]中国科学院生态环境研究中心,中国科学院环境生物技术重点实验室,北京100085

出　　处：《生态毒理学报》2019年第6期317-321,共5页Asian Journal of Ecotoxicology

基　　金：“十三五”国家科技重大专项(2017ZX07107);北京市科技计划课题项目(Z181100005418010)。

摘　　要：啶氧菌酯是一种新型的内吸性杀菌剂,本研究对其水生生物的毒性和累积风险进行了评估。啶氧菌酯原药对斑马鱼的急性毒性试验结果显示,96 h-LC50为0.0509 mg a.i.·L-1。设置0.005 mg·L-1(1/100 LC50)和0.05 mg·L-1(1/10 LC50)2个浓度8 d生物累积试验。在0.005 mg·L-1组,第8天斑马鱼体内啶氧菌酯浓度达到0.48 mg·kg-1,生物富集系数(BCF8 d)缓慢增长到80.00。而在0.05 mg·L-1组,第8天斑马鱼体内的啶氧菌酯浓度为5.27 mg·kg-1,BCF8 d值为99.42。研究表明,啶氧菌酯对斑马鱼为有剧毒,同时具有中等生物累积效应。因此在使用过程中,需要考虑其对水生生物的毒性和水生食物链的放大效应。Picoxystrobin is a broad-spectrum fungicide and will be used extensively in China in the future. To evaluate its risk in aquatic environment, the biotoxicity and bioaccumulation in Brachydanio rerio were studied in the present work. The 96 h-LC50 was 0.0509 mg a.i.·L-1 by acute toxicity test with Brachydanio rerio. 0.005 mg·L-1(1/100 LC50) and 0.05 mg·L-1(1/10 LC50) were used to evaluate the biological availability of picoxystrobin in Brachydanio rerio. In the 0.005 mg·L-1 group, the concentration of picoxystrobin increased on the first day and increased moderately later. The concentration was 0.48 mg·kg-1 in Brachydanio rerio and the bioaccumulation factor(BCF8 d) was 80.00. In the 0.05 mg·L-1 group, the concentration of picoxystrobin increased in the first few days and reached stable in 96 h. The concentration was 5.27 mg·kg-1 in Brachydanio rerio and BCF8 dwas 99.42. The results showed that picoxystrobin was of high toxicity to Brachydanio rerio and medium bioconcentration in Brachydanio rerio. Therefore, the toxicity, bio-accumulation and magnification of picoxystrobin in food chain should be considered during its application.

关 键 词：啶氧菌酯 斑马鱼 急性毒性 生物累积 

分 类 号：X171.5[环境科学与工程—环境科学]