炎症细胞参与侧支循环形成的研究进展  

Research progress in involvement of inflammatory cells in formation of coronary collateral circulation

作　　者：陈帅[1] 丁风华[2] 代杨[1] 陆林[2] 沈迎[2] 沈卫峰[2] CHEN Shuai;DING Feng-hua;DAI Yang;LU Lin;SHEN Ying;SHEN Wei-feng(Institute of Cardiovascular Diseases,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Cardiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院心血管疾病研究所,上海200025 [2]上海交通大学医学院附属瑞金医院心内科,上海200025

出　　处：《上海交通大学学报（医学版）》2020年第3期380-384,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81770447,81870357);上海市教育委员会高峰高原学科建设计划(20181801)。

摘　　要：冠状动脉各分支之间存在丰富的吻合支,当主要冠状动脉闭塞后,冠状动脉侧支循环形成,增加慢性缺血心肌的局部灌注,减少心肌梗死面积。冠状动脉侧支循环主要有2种形成形式:动脉生成和血管新生。当血管阻塞时,不同种类的炎症细胞招募至侧支循环形成区域,对侧支循环形成具有重要的作用。文章探讨不同种类炎症细胞对侧支形成的影响,并进一步分析糖尿病状态下,侧支形成不良的影响因素。There are abundant anastomotic branches among the branches of coronary artery. When the main coronary artery is occluded, the coronary collateral circulation is formed, which increases the local perfusion of ischemic myocardium and reduces the area of myocardial infarction. There are two main forms of coronary collateral circulation: arteriogenesis and angiogenesis. When coronary artery occlusion occurs, different types of inflammatory cells are recruited into the collateral circulation formation area, which plays an important role in coronary collateral circulation formation. This article discusses the effects of different types of inflammatory cells on the formation of coronary collateral circulation, and further describes the contributory factors of poor coronary collateral circulation formation in diabetic patients.

关 键 词：侧支循环 动脉生成 血管新生 炎症细胞 糖尿病 

分 类 号：R363[医药卫生—病理学]