芍药甘草汤的历史沿革与现代研究  

Historical Evolution and Modern Research on Shaoyao Gancaotang

作　　者：曲缘章 马生军 朱广伟[1] 万林春 孙博 李雅静[6] 郭杰 徐腾腾 常阿倩 李刚 杨林勇 李宝国 QU Yuan-zhang;MA Sheng-jun;ZHU Guang-wei;WAN Lin-chun;SUN Bo;LI Ya-jing;GUO Jie;XU Teng-teng;CHANG A-qian;LI Gang;YANG Lin-yong;LI Bao-guo(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Shandong University of Traditional Chinese Medicine(TCM),Ji'nan 250355,China;School of Food Sciences and Pharmacy,Xinjiang Agricultural University,Urumqi 830052,China;Jiangxi Institute for Drug Control,Nanchang 330029,China;Harbin University of Commerce,Harbin 150076,China;Beijing University of Chinese Medicine,Beijing 100102,China;Tianjin University of TCM,Tianjin 300193,China;China Medico Corporation,Tianjin 300301,China;State Key Laboratory of Innovative Natural Medicine and TCM Injections,Jiangxi Qingfeng Pharmaceutical Co.Ltd.,Ganzhou 341000,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]山东中医药大学,济南250355 [3]新疆农业大学食品科学与药学学院,乌鲁木齐830052 [4]江西省药品检验检测研究院,南昌330029 [5]哈尔滨商业大学,哈尔滨150076 [6]北京中医药大学,北京100102 [7]天津中医药大学,天津300193 [8]盛实百草药业有限公司,天津300301 [9]江西青峰药业有限公司创新天然药物与中药注射剂国家重点实验室,江西赣州341000

出　　处：《中国实验方剂学杂志》2020年第6期216-225,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划项目(2018YFC1706500);国家“重大新药创制”科技重大专项(2018ZX09721005);创天然药物与中药注射剂国家重点实验室开放课题(QFSKL2018005)。

摘　　要：芍药甘草汤最早见于张仲景《伤寒杂病论》,由白芍和甘草(炙)等比例配伍而成,具有养血敛阴、调和肝脾、缓急止痛之功效,用于血虚津伤和筋脉失濡所致的腿脚挛急、脘腹疼痛。被历代医家推崇并沿用至今,并且拓展出了应用范围。现代药理研究表明,芍药甘草汤具有显著的解痉、止痛、镇咳、平喘及抗炎等作用,用于治疗痉挛性疾病、疼痛性疾病、炎症性疾病、支气管哮喘及妇产科疾病等。笔者从芍药甘草汤的历史沿革与方义衍变、组方配伍分析、药理药效学研究、现代临床应用4个方面进行系统阐述,以期为该经典名方的现代研究开发提供理论依据和文献参考,并为其制剂的临床定位提供理论和实践支撑。Shaoyao Gancaotang,first seen in Treatise on Febrile and Miscellaneous Diseases,is composed of Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle in equal proportion. It has the functions of preserving Yin to nourish blood,harmonizing liver and spleen,relieving spasm and pain. This formula is applied in leg and foot spasm and abdominal pain caused by blood deficiency,body fluid consuming and the unmoistened muscles and veins. It has been highly praised and used by medical experts throughout the ages and has extended its application scope. Modern pharmacological studies have shown that Shaoyao Gancaotang has significant effects in antispasmodic,analgesic,antitussive and other areas,and is used to treat spastic diseases,painful diseases,inflammatory diseases and so on. This paper will systematically elaborate the historical evolution,compatibility analysis,pharmacological and pharmacodynamic studies,modern clinical application of Shaoyao Gancaotang,in order to provide theoretical basis and reference for the development of this famous classical formula.

关 键 词：芍药甘草汤 经典名方 缓急止痛 历史沿革 临床应用 药理药效 《伤寒杂病论》 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]