卤代甘脲衍生物的合成及杀菌活性  

Synthesis and Fungicidal Activity of Halogenated Glycoluril Derivatives

作　　者：王治国 WANG Zhi-guo(Hubei Key Laboratory of Mine En-vironmental Pollution Control&Remediation,School of Chemistry and Chemical Engineering,Hubei Polytechnic University,Huangshi 435003,China)

机构地区：[1]湖北理工学院化学与化工学院矿区环境污染控制与修复湖北省重点实验室,湖北黄石435003

出　　处：《化学试剂》2020年第3期264-268,共5页Chemical Reagents

基　　金：湖北理工学院校级科研项目(17xjz05A)。

摘　　要：为寻求高效且环保的新型杀菌剂,分别以2,4-(1,3-亚丙基)甘脲和2,4-(1,3-邻苄二基)甘脲为原料,通过氯代、溴代和碘代反应获得两类6种二卤代甘脲衍生物。采用菌落计数法和菌丝生成速率法测试目标衍生物对大肠杆菌、枯草杆菌、金黄色葡萄球菌、酵母菌、链球菌和放线菌等6种常见菌种的杀菌率和EC50值,结果表明卤代甘脲衍生物都具有良好的杀菌活性,且遵循碘取代甘脲>溴取代甘脲>氯取代甘脲的规律。To develope new fungicides with high-effective and environmental advantages,two kinds of six dihalogenated glycoluril derivatives were synthesized based on chlorination reaction,bromination reaction and iodination reaction using 2,4-(1,3-propylidene) glycoluril and 2,4-(1,3-o-benzyl) glycoluril as starting materials,respectively.Based on dihalogenated glycoluril derivatives on six common species escherichia coli,bacillus subtilis,staphylococcus aureus,saccharomyces cerevisiae,streptococcus and actinomycete,colony counting method was used for determining sterilizing rate,and mycelium formation rate method was used for obtaining the EC50 values.The target halogenated glycoluril derivatives had good fungicidal activity,followed the regularities of iodinated glycoluril,brominated glycoluril and chlorinated glycoluril.

关 键 词：甘脲 卤代反应 衍生物 合成 杀菌剂 杀菌活性 

分 类 号：R914.5[医药卫生—药物化学]