肠道菌群代谢产物氧化三甲胺与缺血性脑血管病关系的研究进展  

Recent advance in relation between trimethylamine oxide metabolized by intestinal microbes and ischemic cerebrovascular diseases

作　　者：李彩珍 蒋超[1] Li Caizhen;Jiang Chao(Department of Neurology,Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院神经内科,郑州450052

出　　处：《中华神经医学杂志》2020年第3期310-315,共6页Chinese Journal of Neuromedicine

摘　　要：氧化三甲胺是胆碱等营养物质经肠道菌群与肝酶代谢生成的产物。近年来,国内外研究发现氧化三甲胺在缺血性脑血管病的发生发展过程中具有重要作用,其可通过干扰胆固醇的逆向转运、胆汁酸的合成、上调与动脉粥样硬化发生相关的巨噬细胞受体的表达、参与血管内皮细胞炎症反应、影响血小板聚集及血栓形成潜能等方面参与缺血性脑血管病的发生发展。笔者现就氧化三甲胺的产生过程、氧化三甲胺在缺血性脑血管病发生发展等方面的作用的研究进展进行综述,以期深入了解与氧化三甲胺相关的缺血性脑血管病的发病机制及病理生理过程,并促进该领域临床转化医学研究的发展。Trimethylamine oxide(TMAO)is a product of the metabolism of nutrients such as choline by intestinal microbes and liver enzymes.Recent studies have revealed that TMAO may be essential for occurrence and development of cerebrovascular diseases by disturbing the reverse transport of cholesterol,upregulating expressions of macrophage receptors associated with development of atherosclerosis,synthesis of bile acids,vascular endothelial cell inflammation,platelet aggregation and thrombosis.In this paper,we review recent studies about the production of TMAO,and efficacy of TMAO in occurrence and development of ischemic cerebrovascular diseases.This review will help us to understand TMAO related pathogenesis and pathophysiological process of ischemic cerebrovascular diseases and to identify potential therapeutic targets to facilitate translational research in this field.

关 键 词：缺血性脑血管病 氧化三甲胺 肠道菌群 

分 类 号：R74[医药卫生—神经病学与精神病学]