慢性炎性脱髓鞘性多发性神经根神经病发病机制的研究进展  

Recent advance in pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy

作　　者：冯园 卢祖能[1] Feng Yuan;Lu Zuneng(Department of Neurology,People's Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院神经内科,武汉430060

出　　处：《中华神经医学杂志》2020年第3期316-319,共4页Chinese Journal of Neuromedicine

摘　　要：慢性炎性脱髓鞘性多发性神经根神经病(CIDP)是一类由免疫介导的慢性致残性运动感觉神经脱髓鞘性神经病。其发病机制不明,临床表现复杂,诊断困难,治疗效果欠佳。因为CIDP患者对免疫治疗反应良好,目前认为该病为自身免疫性疾病,但具体启动免疫损伤机制的致病抗原及作用靶点尚不清楚。本文将从细胞免疫的致病过程以及体液免疫中相关蛋白这两方面综述CIDP的可能发病机制。Chronic inflammatory demyelinating polyradiculoneuropathy(CIDP)is a motor-sensory demyelinating neuropathy mediated by immunity.The pathogenesis is still unclear,and the clinical manifestations are complex.Its diagnoses are difficult,and the treatment effect is not good.At present,most studies consider it to be an autoimmune disease,but the pathogenic antigen and its target to the immune damage mechanism of the disease are still unclear.In this paper,we review the literature on the pathogenesis of CIDP in recent years,and introduce the specific mechanisms which cause CIDP from cellular and humoral immunity.

关 键 词：慢性炎性脱髓鞘性多发性神经根神经病 膜攻击复合物 接触蛋白-1 神经束蛋白155 神经束蛋白186 

分 类 号：R74[医药卫生—神经病学与精神病学]