广藿香醇药理作用研究进展  

Advances in Pharmacological Studies of Patchouli Alcohol

作　　者：张伟[1] 张娟娟[1] 郭庆丰[1] 陈林[1] 尹震花[1] ZHANG Wei;ZHANG Juan-juan;GUO Qing-feng;CHEN Lin;YIN Zhen-hua(Zhengzhou Key Laboratory of Synthetic Biology of Natural Products,Henan Joint International Research Laboratory of Drug Discovery of Small Molecules,Huanghe Science and Technology University,Zhengzhou 450063,China)

机构地区：[1]黄河科技学院郑州市天然产物合成生物学重点实验室,河南省小分子新药研发国际联合实验室,郑州450063

出　　处：《中国实验方剂学杂志》2020年第3期213-221,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省科技厅产学研合作项目(182107000033);河南省教育厅高等学校重点科研项目(18A360019,19B360007)。

摘　　要：广藿香醇(PA)是广藿香的主要活性成分,药理研究表明,PA具有抗炎、抗胃溃疡、抗癌、保护肺和脑损伤、抗菌、预防乳腺炎、结肠炎和动脉粥样硬化、抗光老化、治疗腹泻型肠易激综合征、抗氧化应激、血管舒张和抗伤害等多种作用,初步的作用机制研究表明,其抗炎作用与下调炎症介质的mRNA表达来抑制促炎细胞因子产生及减少细胞外调节蛋白激酶(ERK)介导的NF-JB活化等有关;抗胃溃疡、保护肺损伤和脑损伤及抗光老化作用的作用与其抗氧化和抗炎作用有关;PA抑制MV4-11细胞增殖和诱导其凋亡可能与核转录因子-κB(NF-κB),磷酸化M2型丙酮酸激酶(p-PKM2)和半胱氨酸蛋白酶-3(Caspase-3)蛋白表达发生明显改变有关;其抗人结直肠癌细胞作用可能与抑制组蛋白去乙酰化酶(HDAC)-2的表达和HDAC酶活性,以及随后下调c-myc和激活NF-κB通路有关;通过阻断表皮生长因子受体(EGFR)通路的磷酸化和激活c-Jun氨基末端激酶(JNK)诱导A549癌细胞凋亡;抗前列腺癌与线粒体细胞色素C凋亡途径激活有关;其抗病毒作用可能与调节1型螺旋酶(RLH)信号通路或与病毒蛋白或核酸以及病毒与细胞结合的位点直接结合来阻断病毒吸附细胞;其抗菌、预防乳腺炎、结肠炎和动脉粥样硬化作用机制与抗炎有很大的关系,PA的药理作用仍需进一步的研究。为了加快PA药理作用分子机制的探索和发现,扩大其应用前景,本文综述了近10年来PA的代谢、生物活性及其可能的作用机制,以期为PA的开发和应用提供参考。Patchouli Alcohol(PA)is the main bioactive constituent of Pogostemon cablin Pharmacological researches have reported various benefits of PA,including anti-infammatory,anti-gastric ulcer,anticancer,protecting against alung and brain injury,antibacterial,prevention of mastitis,colitis and arteriosclerosis,anti-photoaging,treatment of diarrhea irritable bowel syndrome,antioxidant stress,vasodilation and anti-injury.The preliminary study on the mechanism showed that anti-inflammatory effect was related to the down-regulation of mRNA expression of inflammatory mediators to inhibit the production of proinflammatory cytokines and the reduction of extracellular regulated protein kinases(ERK)-mediated nuclear factor kappa B(NF-κB)activation.The anti-gastric ulcer,protection of lung injury and brain injury and anti-photoaging were related to antioxidant and anti-inflammatory effects.The mechanism of anti-human leukemic cell line MV4-11 migh be associated with the changes of NF-κB,phosphorylated M2 pyruvate kinase(p-PKM2)and cysteine aspartate protease-3(Caspase-3)protein expressions.The proposed mechanisms of anti-human colorectal cancer cells included the inhibition of histone deacetylase(HDAC)-2 expression and HDAC enzyme activity,and subsequent downregulation of c-myc and activation of NF-κB pathway.Apoptosis of A549 cells was induced by blocking the phosphorylation of epidermal growth factor receptor(EGFR)pathway and activating c-Jun N-terminal kinase(JNK).Anti-prostate cancer was related to the activation of mitochondrial cytochrome C apoptosis pathway,and its antiviral effect may be related to the regulation of RIG-1-like helicases(RLH)signal pathway or the direct binding of virus protein or nucleic acid and the binding site of virus to cells to block the adsorption of virus to cells.The mechanism of its antibacterial,prevention of mastitis,colitis and arteriosclerosis was closely related to antiinflammation.The pharmacological effects of PA need to be further studied.In order to accelerate the exploration and dis

关 键 词：广藿香醇 抗炎 抗胃溃疡 抗癌 抗菌 抗氧化应激 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]