G1-熵权法联合响应面法优选百清胶囊浸膏的减压干燥工艺  

Optimization of vacuum drying process for extract paste of Baiqing Capsules by G1-entropy and response surface method

作　　者：曹苗苗[1,2] 许明君[1,2] 于桂芳[1,2] 高如意[1,2] 柏伟荣[1,2] CAO Miaomiao;XU Mingjun;YU Guifang;GAO Ruyi;BAI Weirong(Jiangsu Kanion Pharmaceutical Co.,Ltd,Lianyungang 222001,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Lianyungang 222001,China)

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中药制药过程新技术国家重点实验室,连云港222001

出　　处：《西北药学杂志》2020年第2期196-200,共5页Northwest Pharmaceutical Journal

基　　金：国家重点研发计划“中医药现代化研究”重点专项(编号:2017YFC1703000)。

摘　　要：目的优选百清胶囊浸膏的减压干燥工艺。方法以斯皮诺素和总皂苷含量及干燥速率的综合评分为考察指标,运用G1-熵权法确定各指标的权重系数,通过响应面实验考察影响因素真空度、干燥温度和物料铺盘厚度,优选减压干燥工艺。结果浸膏最佳减压干燥工艺条件为真空度0.07 MPa,干燥温度72℃,物料铺盘厚度6 mm。该条件下的减压干燥综合评分为98.49,模型预测值为97.81,RSD值为0.70%。结论优选的减压干燥工艺稳定、可行,可为百清胶囊的工业化生产提供数据支持。Objective To optimize the vacuum drying process for extract paste of Baiqing Capsules.Methods The comprehensive scores of the contents of sipinuosu,total saponins and drying rate were taken as the evaluation index.The weight coefficient of each index was determined by G1-entropy method.The number of influencing factors,the vacuum degree,drying temperature and material thickness were optimized through response surface experiment to optimize the vacuum drying process.Results The optimal vacuum drying parameters were as follows:the vacuum degree was 0.07 MPa,the drying temperature was 72℃,and the material thickness was 6 mm.Under these conditions,the average comprehensive score of vacuum drying was 98.49,while the model prediction value was 97.81,RSD was 0.70%.Conclusion The optimized vacuum drying process is stable and feasible,which can provide data support for industrialization of Baiqing Capsules.

关 键 词：百清胶囊 减压干燥 响应面法 G1-熵权法 

分 类 号：R94[医药卫生—药剂学]