丁苯酞与尤瑞克林治疗急性期脑梗死的疗效及对远期神经功能恢复的影响比较  被引量:5

Comparison on the Effect of Butylphthalide and Urinary Kallidinogenase on the Patients with Acute Cerebral Infarction and the Influence on the Recovery of Long-term Nerve Function

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作  者:郭丽莎[1] 孙强[1] 邢惠娟 刘晓琳[1] 方骁[1] GUO Lisha;SUN Qiang;XING Huijuan;LIU Xiaolin;FANG Xiao(The Third People’s Hospital of Dalian,Dalian 116033,China)

机构地区:[1]辽宁省大连市第三人民医院,辽宁大连116033

出  处:《中国医学创新》2020年第6期21-24,共4页Medical Innovation of China

摘  要:目的:观察丁苯酞与尤瑞克林治疗急性期脑梗死的疗效及对远期神经功能恢复的影响。方法:选取2017年8月-2018年9月于本院接受治疗的69例急性脑梗死患者为研究对象。根据治疗方式的不同将其分为对照组(尤瑞克林)36例和治疗组(丁苯酞)33例。比较两组治疗后的临床疗效、治疗前后的NIHSS评分、Barthel指数、神经功能相关血液指标[神经元特异性烯醇化酶(NSE)]。结果:两组急性期(治疗2周)的总有效率比较,差异无统计学意义(x^2=0.037,P=0.847);治疗组恢复期(治疗3、6个月)的临床总有效率分别为84.85%、93.94%,均高于对照组的63.89%、75.00%,差异均有统计学意义(x^2=3.923、4.609,P=0.047、0.031)。治疗前、治疗2周,两组NIHSS评分及Barthel指数评分比较,差异均无统计学意义(P>0.05);治疗3、6个月,治疗组的NIHSS评分及Barthel指数评分均显著优于对照组,差异均有统计学意义(P<0.05)。治疗前、治疗2周,两组NSE水平比较,差异均无统计学意义(P>0.05);治疗4周,治疗组NSE水平显著低于对照组,差异有统计学意义(P<0.05)。结论:丁苯酞治疗急性期脑梗死的疗效优与尤瑞克林相当,但序贯治疗后对远期神经功能恢复的影响更为有效,因此在急性脑梗死患者中的应用价值更高。Objective:To observe the effect of Butylphthalide and Urinary Kallidinogenase on the patients with acute cerebral infarction and the influence on the recovery of long-term nerve function.Method:A total of69 patients with acute cerebral infarction who were treated in our hospital from August 2017 to September 2018 were selected as the study objects.According to the different treatment methods,they were divided into the control group (Urinary Kallidinogenase) 36 cases and the treatment group (Butylphthalide) 33 cases.The clinical effects after treatment,NIHSS score,Barthel index,nerve function related blood index [neuron specific enolase (NSE)] before and after treatment of the two groups were compared.Result:The total effective rate of the two groups in the acute stage (2 weeks of treatment) was compared,the difference was not statistically significant (x^2=0.037,P=0.847);the total clinical effective rates in the recovery period (3 and 6 months of treatment) in the treatment group were 84.85% and 93.94%,respectively,which were significantly higher than 63.89% and 75.00% in the control group,the differences were statistically significant (x^2=3.923,4.609,P=0.047,0.031).Before and after treatment for 2 weeks,the NIHSS score and Barthel index score of the two groups were compared,the differences were not statistically significant (P>0.05);3 and 6 months of treatment,the NIHSS score and Barthel index score of the treatment group were significantly better than those of the control group,the differences were statistically significant (P<0.05).Before and after treatment for 2 weeks,the NSE levels of the two groups were compared,the differences were not statistically significant (P>0.05);4 weeks of treatment,the NSE level in the treatment group was significantly lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion:The therapeutic effect of Butylphthalide in the treatment of acute cerebral infarction is better than that of Urinary Kallidinogenase,but the effect of sequential

关 键 词:丁苯酞 尤瑞克林 急性期脑梗死 远期神经功能 

分 类 号:R743.3[医药卫生—神经病学与精神病学]

 

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