丙戊酸钠辅助治疗感染性脑炎所致精神障碍伴攻击行为患者的效果  

Effect of Sodium Valproate in the Adjuvant Treatment of Patients with Mental Disorders and Aggressive Behavior Caused by Infective Encephalitis

作　　者：李坤[1] 陈天灵 熊伟[1] 黄冬竹 常大川[1] LI Kun;CHEN Tianling;XIONG Wei;HUANG Dongzhu;CHANG Dachuan(The First Naval Hospital of the Southern Theater of the Chinese People’s Liberation Army,Zhanjiang 524000,China)

机构地区：[1]中国人民解放军南部战区海军第一医院,广东湛江524000

出　　处：《中国医学创新》2020年第7期112-115,共4页Medical Innovation of China

摘　　要：目的:探讨丙戊酸钠辅助治疗感染性脑炎所致精神障碍伴攻击行为患者的临床应用效果。方法:选取2015年5月-2019年5月本院精神心理科及相关科室收治的感染性脑炎致精神障碍伴攻击行为患者62例。根据随机数字表法,将其分为对照组和观察组,各31例。对照组给予利培酮治疗,观察组在对照组基础上联合应用丙戊酸钠。比较两组患者治疗前后PAN-SS评分、MOAS评分、治疗有效率和不良反应发生情况。结果:治疗前,两组的阳性因子、阴性因子、一般精神病理评分比较,差异均无统计学意义(P>0.05);治疗后,两组上述各维度评分均显著低于治疗前,且观察组均显著低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组言语攻击、财产攻击、体力攻击、自身攻击评分比较,差异均无统计学意义(P>0.05);治疗后,两组上述各维度评分均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率为93.55%,显著高于对照组的70.97%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对于感染性脑炎所致精神障碍伴攻击行为患者的治疗,在利培酮基础上联合丙戊酸钠可显著提高治疗效果,控制患者的精神症状和攻击行为,且用药安全性良好,值得临床推广。Objective:To explore the clinical effect of Sodium Valproate in the treatment of patients with mental disorder and aggressive behavior caused by infectious encephalitis.Method:A total of 62 patients with mental disorders and aggressive behaviors caused by infectious encephalitis admitted to the Department of psychiatry and related Departments of our hospital from May 2015 to May 2019 were selected.According to the random number table method,the patients were divided into control group and observation group,31 cases in each group.The control group was treated with Risperidone,the observation group was treated with Sodium Valproate in combination with the control group.PAN-SS score,MOAS score,effective rate and adverse reactions in the two groups were compared before and after treatment.Result:Before the treatment,the positive factors,negative factors and general psychopathological scores of the two groups were compared,the differences were not statistically significant(P>0.05).After treatment,the scores of the above dimensions in both groups were significantly lower than those before treatment,and the observation group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).Before the treatment,comparison of verbal aggression,property aggression,physical aggression and self-aggression scores between the two groups,the differences were not statistically significant(P>0.05).After treatment,the scores of the above dimensions in both groups were lower than those before treatment,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 93.55%,significantly higher than 70.97%of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions was compared between the two groups,the difference was not statistically significant(P>0.05).Conclusion:For the treatment of patients with mental disorder

关 键 词：感染性脑炎 精神障碍 攻击行为 利培酮 丙戊酸钠 

分 类 号：R749[医药卫生—神经病学与精神病学] R742.9[医药卫生—临床医学]