丁苯酞对脑梗死再灌注患者血清中枢神经特异性蛋白、糖分解烯醇酶及神经功能缺损的影响  

Analysis of serum S-100 beta protein,NSE and neurological deficits in patients with cerebral infarction and reperfusion treated with butylphthalide

作　　者：朱乃刚 Zhu Naigang(Department of Neurology,the Peoples Hospital of Feicheng,Taian,Shandong 271600,China)

机构地区：[1]肥城市人民医院神经内科,山东271600

出　　处：《中国基层医药》2020年第4期403-407,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨丁苯酞对脑梗死再灌注患者血清中枢神经特异性蛋白(s-100β)、糖分解烯醇酶(NSE)及神经功能缺损的影响.方法选取肥城市人民医院2016年1月至2018年1月收治的早期脑梗死患者104例为研究对象,均经临床检查确诊和溶栓治疗.采用随机数字表法分为两组,对照组(n=52)给予常规治疗,观察组(n=52)在对照组基础上给予丁苯酞治疗,比较两组患者溶栓前后神经功能缺损程度和血清NSE及s-100β蛋白水平.结果溶栓前两组患者NIHSS评分分别为(10.27±1.32)分、(10.28±1.30)分,差异无统计学意义(t=0.038,P>0.05);溶栓后24h、7d两组患者神经功能缺损评分(NIHSS)均下降,观察组评分分别为(8.32±1.37)分、(4.25±1.54)分,均显著低于对照组的(9.24±1.40)分、(9.50±1.24)分,差异均有统计学意义(t=3.396、19.147,均P<0.05).溶栓前两组患者血清NSE水平分别为(22.56±5.78)U/mL、(22.58±5.77)U/mL,差异无统计学意义(t=0.017,P>0.05);溶栓后24 h、7d两组患者血清NSE水平均下降,观察组分别为(15.08±9.35)U/mL、(13.25±6.47)U/mL,均显著低于对照组的(18.96±10.14)U/mL、(16.98±7.11)U/mL,差异均有统计学意义(t=2.028、2.798,均P<0.05).溶栓前两组患者血清s-100β蛋白水平分别为(1.26±0.71)μg/L、(1.27±0.70)μg/L,差异无统计学意义(t=0.072,P>0.05);溶栓后24 h、7d两组患者血清s-100β蛋白水平均下降,观察组分别为(1.13±0.62)μg/L、(0.53±0.48)μg/L,均显著低于对照组的(1.40±0.64)μg/L、(0.87±0.32)μg/L,差异均有统计学意义(t=2.185、4.250,均P<0.05).结论丁苯酞治疗脑梗死再灌注能有效促进患者神经功能恢复,改善血清NSE、s-100β蛋白水平,有助于患者康复.Objective To investigate the effects of butylphthalide on serum S-100 beta protein,NSE and neurological deficits in patients with cerebral infarction and reperfusion.Methods From January 2016 to January 2018,104 patients with early cerebral infarction admitted to the People s Hospital of Feicheng were divided into two groups according to different treatment methods.The control group(n=52)was given routine treatment,while the observation group(n=52)was given butylphthalide treatment on the basis of the control group.The degree of neurological deficit,serum NSE and S—100 beta protein levels were compared between the two groups before and after thrombolysis.Results The NIHSS scores of the two groups before thrombolysis were(10.27±1.32)points and(10.28±1.30)points,respectively,the difference between the two groups was no statistically significant(t=0.038,P>0.05).The NIHSS scores of the two groups were decreased at 24h and 7d after thrombolysis,which of the observation group at 24h and 7d after thrombolysis were(8.32±1.37)points and(4.25±1.54)points,respectively,which were significantly lower than those of the control group[(9.24±1.40)points and(9.50±1.24)points],the differences were statistically significant(t=3.396,19.147,all P<0.05).The serum NSE levels of the two groups before thrombolysis were(22.56±5.78)U/mL and(22.58±5.77)U/mL,respectively,the difference between the two groups was no statistically significant(t=0.017,P>0.05).At 24h and 7d after thrombolysis,the serum NSE levels of the two groups were decreased.The sennn NSE levels of the observation group at 24h and 7d after thrombolysis were(15.08±9.35)U/mL and(13.25±6.47)U/mL,respectively,which were significantly lower than those in the control group[(18.96±10.14)U/mL and(16.98±7.11)U/mL],the differences were statistically significant(￡=2.028,2.79,all P<0.05).The serum S-100p protein levels in the two groups before thrombolysis were(1.26±0.71)pug/L and(1.27±0.70)p,g/L,respectively,and the difference was not significant(t=0.0723,P>0.05).At 24

关 键 词：梗塞 大脑中动脉 再灌注 血清S-100Β蛋白 NSE 神经功能缺损 丁苯酞 

分 类 号：R74[医药卫生—神经病学与精神病学]