前列腺导管内癌患者临床病理特征及预后研究  

CLINICOPATHOLOGICAL FEATURES AND PROGNOSIS OF INTRADUCTAL CARCINOMA OF THE PROSTATE

作　　者：陈欣怡[1] 谷勤勤 亓永云 韩博[2] CHEN Xinyi;GU Qinqin;QI Yongyun;HAN Bo(Department of Pathology,Qingdao Central Hospital,The Second Affiliated Hospital of Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛大学第二附属医院青岛市中心医院病理科,山东青岛266042 [2]山东大学齐鲁医院病理科

出　　处：《精准医学杂志》2020年第1期30-32,37,共4页Journal of Precision Medicine

基　　金：国家自然科学基金资助项目(81672554)。

摘　　要：目的比较前列腺导管内癌(IDC-P)组和非IDC-P组患者临床病理特征及预后。方法对山东大学齐鲁医院确诊为前列腺癌的282例穿刺标本进行回顾性分析,通过免疫组化方法确定IDC-P的发生情况,记录IDC-P组和非IDC-P组患者的年龄、术前前列腺特异抗原(PSA)水平、术前骨转移情况、临床T分期、Gleason分级分组,并通过电话随访记录两组患者的总生存和疾病特异生存情况,最后进行比较。结果检测出IDC-P患者21例,IDC-P在前列腺癌中的构成比为7.45%(21/282)。IDC-P组患者术前PSA水平升高、发生骨转移患者构成比明显高于非IDC-P组患者(χ^2=7.019、5.392,P<0.05)。Kaplan-Meier生存分析显示,IDC-P组患者的总生存率及疾病特异生存率均显著低于非IDC-P组患者(χ^2=9.964、10.294,P<0.05)。Cox模型多因素分析显示,IDC-P是前列腺癌患者总生存及疾病特异生存的独立危险因素(Waldχ^2=4.580、4.498,P<0.05)。结论IDC-P是影响前列腺癌患者预后的独立危险因素。Objective To compare clinicopathological features and prognosis between patients with intraductal carcinoma of the prostate(IDC-P)and non-IDC-P patients with prostate cancer.Methods A retrospective analysis was performed on biopsy specimens from 282 patients who were confirmed with prostate cancer in Qilu Hospital of Shandong University.The patients with IDC-P were identified by immunohistochemistry.The IDC-P group and the non-IDC-P group were compared in terms of age,preoperative prostate-specific antigen(PSA)level,preoperative bone metastases,clinical T stage,and Gleason grade,as well as their overall survival and disease-specific survival,which were recorded by telephone follow-up.Results Twenty-one cases of IDC-P were detected,accounting for 7.45%of all prostate cancer patients.The IDC-P group had significantly higher proportions of patients with an increased preoperative PSA level and those with bone metastases than the non-IDC-P group(χ^2=7.019,5.392,P<0.05).Kaplan-Meier survival analysis showed that the overall survival rate and disease-specific survival rate were significantly lower in the IDC-P group than in the non-IDC-P group(χ^2=9.964,10.294,P<0.05).Multivariate Cox analysis showed that IDC-P was an independent risk factor for overall survival and disease-specific survival(Waldχ^2=4.580,4.498,P<0.05).Conclusion IDC-P is an independent risk factor affecting the prognosis of patients with prostate cancer.

关 键 词：癌 导管内 前列腺肿瘤 病理学 预后 存活率 

分 类 号：R737.25[医药卫生—肿瘤]