滋补酥油颗粒成型工艺研究  

Study on molding process of Zibu Suyou granule

作　　者：韩珊颖 钟绍金 HAN Shanying;ZHONG Shaojin(Department of Pharmacy,The Affiliated Haikou Hospital of Xiangya Medical College,Central South University,Haikou,Hainan 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院药学部,海南海口570208

出　　处：《安徽医药》2020年第4期670-673,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的优选滋补酥油颗粒的成型工艺。方法2017年10月至2018年10月,以油腻感和吸附效果为评价指标,优选吸附剂种类及用量;以颗粒得率、成型性、溶化性及流动性为评价指标,优选赋形剂种类及配比;通过测定脆碎度,评价颗粒的抗压能力,优选黏合剂;以甜味程度为指标,优选矫味剂用量;最后以水分含量为指标,考察颗粒的烘干工艺。结果最佳工艺为:将浸膏、蜂蜜与酥油按原处方比例混合加热熔融,按药物混合物与交联聚乙烯吡咯烷酮(PVPP)3.5∶1的比例加入PVPP混匀;再按原处方比例称取人参、鹿茸和冬虫夏草的药材粉末(过100目),按等量递增法与混合辅料(糊精∶可溶性淀粉=1∶1)及冰糖粉(25%主药量)混匀;将两种混合物合并混匀,以50%乙醇[含5%聚乙烯吡咯烷酮(PVP)]作黏合剂湿法挤压制粒,以60℃的温度烘干4 h后,整粒,即得;成品颗粒得率高,成型性好,口感适宜。结论筛选出的制粒工艺简便可行,对藏药改剂具有一定的借鉴意义。Objective To optimize the molding process of Zibu Suyou Granule.Methods From October 2017 to October 2018,greasy feeling and adsorption effect were selected as evaluation indicators to optimize the type and amount of adsorbent;the particle yield,formability,meltability and fluidity were selected as evaluation indicators to optimize the excipient types and ratios;the friabil ity was measured and the pressure resistance of the particles were evaluated to optimize the binder;the degree ofsaccharinity was selected as the indexes to optimizecorrectantdosage.Finally,the moisture content was used as an indicator to investigate the drying process of the particles.Results The best process is mixing the extract,honey and ghee in the original prescription with heating and melting,add PVPP according to the ratio of drug mixture to PVPP 3.5∶1;weigh the powder of ginseng,velvet and Cordyceps si nensis according to the original prescription ratio(over 100 mesh),then mix in equal increments with mixed excipients(Dextrin∶soluble starch=1∶1)and rock candy powder(25%main dose).Mix the two mixtures,using 50%ethanol(containing5%PVP)as binder to conduct wet extrusion granulation,we can get satisfactory particles after drying at 60℃ for 4 h and breaking.The finished product had high grain yield,good formability,and pleasant taste.Conclusion The screened forming process is convenient and practicable,which has certain reference significance for dosage form changing of Tibetan medicine.

关 键 词：剂型改进/方法 冲剂/生产和制备 蜂蜜 聚维酮 藏药 滋补酥油颗粒 

分 类 号：TQ461[化学工程—制药化工]