布-加综合征模型的构建及进展  

Establishment of Budd-Chiari syndrome models and related research advances

作　　者：王立博 孙玉岭[1,2,3] WANG Libo;SUN Yuling(Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)

机构地区：[1]郑州大学第一附属医院肝胆胰外科,郑州450052 [2]郑州大学肝胆胰疾病研究所,郑州450052 [3]郑州市肝胆胰疾病基础与临床研究重点实验室,郑州450052

出　　处：《临床肝胆病杂志》2020年第4期908-911,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81870457,81900558)。

摘　　要：布-加综合征是由肝静脉或其开口以上的下腔静脉阻塞引起的门静脉高压伴或不伴有下腔静脉高压的临床综合征,中国人群主要以下腔静脉隔膜形成和(或)阶段性合并肝静脉梗阻为特征。目前人们对布-加综合征的病因和发病机制所知甚少,所做研究多为诊治策略方面的临床研究,针对其发病机制的实验探索相对稀缺,而稳定模型往往是疾病机制研究的必要条件。就目前布-加综合征模型的构建方法、各种模型的特点和研究进展作一综述和分析,以便为该病病因和发病机制的探索提供可靠的实验基础。Budd-Chiari syndrome(BCS)is a clinical syndrome of portal hypertension caused by the occlusion of the hepatic vein or the inferior vena cava,with or without inferior vena cava hypertension,and the formation of inferior vena cava diaphragm and/or hepatic venous obstruction are the main features in the Chinese population.At present,little is known about the etiology and pathogenesis of BCS,and most of the studies are clinical studies of diagnosis and treatment strategies.There is a lack of experimental exploration and research on the pathogenesis of BCS,and stable models are a necessary condition for the research on pathogenesis.This article reviews and analyzes the methods for establishing BCS models,the features of each model,and related research advances,in order to provide a reliable experimental basis for the research on the etiology and pathogenesis of BCS.

关 键 词：BUDD-CHIARI综合征 高血压 门静脉 疾病模型 动物 

分 类 号：R575[医药卫生—消化系统]