程序性坏死与视网膜疾病相关性的研究进展  

Research advance on the correlation between programmed necrosis and retinal diseases

作　　者：许雲 何媛[2] XU Yun;HE Yuan(Department of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China;Xi’an Medical University,Xi’an 710068,Shaanxi Province,China)

机构地区：[1]西安医学院,陕西省西安市710068 [2]西安医学院第二附属医院眼科,陕西省西安市710038

出　　处：《眼科新进展》2020年第3期284-289,共6页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号81100665,81770929);陕西省教育厅2018年服务地方科学研究计划资助(编号18JC026);陕西省科技厅项目资助(编号2019SF-162)。

摘　　要：程序性坏死是由分子受体相互作用蛋白激酶1、分子受体相互作用蛋白激酶3和混合系激酶区域蛋白介导的一种不同于凋亡及传统坏死的细胞程序性死亡方式,可由肿瘤坏死因子受体或模式识别受体调控启动。越来越多的研究发现,程序性坏死在视网膜疾病发生和发展中起关键作用。本文将对程序性坏死的分子机制及程序性坏死与视网膜疾病相关性的研究进展进行综述,以帮助寻找治疗视网膜疾病的新靶点。Programmed necrosis is a programmed cell death different from apoptosis and traditional necrosis.It is mediated by receptor-interacting protein RIP kinase 1(PIRK1),PIRK3 and mixed lineage kinase domain-like protein,adjusted and initiated through many factors such as tumor necrosis factor receptor or pattern recognition receptor.More and more evidence indicates that programmed necrosis plays an important role in the occurrence and development of retinal diseases.In this review,we will discuss the molecular mechanisms of programmed necrosis and the correlation between programmed necrosis and retinal diseases,in order to help find new targets for the treatment of retinal diseases.

关 键 词：程序性坏死 视网膜疾病 视网膜色素变性 

分 类 号：R774.1[医药卫生—眼科]