玉米赤霉烯酮对小鼠血清生化指标及肝脏、肾脏组织结构的影响  

Effects of zearalenone on serum biochemical parameters,histological structure of liver and kidney of mice

作　　者：王丙雷 崔亚利[1] 王飞[1] 周令强 陈宝江[2] 崔嘉[2] WANG Bing-lei;CUI Ya-li;WANG Fei;ZHOU Ling-qiang;CHEN Bao-jiang;CUI Jia(College of Veterinary Medicine,Hebei Agricultural University,Baoding,Hebei 071000,China;College of Animal Science and Technology,Hebei Agricultural University,Baoding,Hebei 071000,China)

机构地区：[1]河北农业大学动物医学院,河北保定071000 [2]河北农业大学动物科技学院,河北保定071000

出　　处：《中国兽医学报》2020年第3期581-587,共7页Chinese Journal of Veterinary Science

基　　金：中国-欧盟饲料霉菌毒素生物脱毒关键技术合作研究项目(S2016G4513)。

摘　　要：将80只4周龄体质量18~22g昆明雌性小鼠随机分为4组。对照组饲喂基础日粮,试验1、2、3组在基础日粮中分别添加50,100,150mg/kg ZEA,预试期7d,试验期20d。结果显示,饲粮中添加100~150mg/kg ZEA后,发情前期和发情期血清中BUN和LDL含量极显著升高(P<0.01),TP、HDL、TC、TG的含量变化没有明显的规律;发情前期和发情期血清中MDA含量极显著升高(P<0.01),T-AOC、T-SOD、GSH-Px活性极显著降低(P<0.01);肾小球和肾小管萎缩。结果表明,饲粮中添加100~150mg/kg ZEA后,极显著的降低了小鼠抗氧化能力,肾实质损伤显著。Eighty female mice,4-week-old,weighing 18-22g,were randomly divided into 4groups.The mice in the control group were fed with the basal diet.The diet for the experimental group1,2 and 3 was added with ZEA of 50,100and 150mg/kg respectively in the basal diet.Preliminary trial period was 7days,and the test period was 20days.The results showed that the diet with addition of 100-150mg/Kg ZEA increased the levels of BUN and LDL in serum of pre-estrus and estrus period(P<0.01).No obvious regularity in the changes of TP,HDL,TC and TG contents present.Adding 100-150mg/kg ZEA to the diet increased the serum MDA levels in pre-estrus and estrus period significantly(P<0.01),and significantly decreased the activity of T-AOC、T-SOD、GSH-Px(P<0.01).Glomerular and tubular atrophy were observed.Diet addition with 100-150mg/kg ZEA decreased significantly the antioxidant capacity of mice.Severe renal parenchymal damage was observed.

关 键 词：玉米赤霉烯酮 小鼠 生化指标 抗氧化性 

分 类 号：S816[农业科学—饲料科学] S852[农业科学—畜牧学]