不同亚型急性缺血性脑卒中患者采用丁苯酞注射液效果比较  

Effects of butylphthalide injection in patients with acute ischemic stroke in different subtypes

作　　者：杨春伍[1] YANG Chunwu(Shuyang county central hospital Jiangsu 22360 China)

机构地区：[1]沭阳县中心医院,江苏宿迁223600

出　　处：《中国急救复苏与灾害医学杂志》2020年第3期307-310,共4页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的观察不同牛津郡社区卒中计划(oxfordshire coxninunity stroke project,OCSP)分型急性缺血性脑卒中患者采用丁苯酞注射液的治疗效果。方法选取在沭阳县中心医院2018年11月30日-2019年5月30日收治的68例急性缺血性脑卒中患者为观察组,选取同期收治的68例急性缺血性脑卒中患者作为对照组。对照组接受常规急性缺血性脑卒中治疗,观察组在对照组基础上加用丁苯酞注射液。患者入院时均进行OCSP分型。观察两组患者及不同OCSP患者治疗前后NIHSS评分和BI评分、治疗效果。结果两组治疗前NIHSS评分及BI评分差异无綵计学意义(P>0.05)。治疗后14 d,观察组NIHSS评分较对照组降低,BI评分较对照纽升高,总有效率较汾照组高,差异有统计学意义(P<0.05)。观察组和对照组不同OCSP分型患者治疗后NIHSS评分均较治疗前降低,BI评分较治疗前升高,差异有统:计学意义(P<0.05)。组间比较,观察组完全前循环梗死(total anterior circulation inferction,TACI)、部分前循环梗死(partial anterior circulation infarction,PACI)、腔隙性前循环梗死(Lacunar anterior circulation inferction,LACI)患者治疗14d后NIHSS评分较对照组降低,BI评分较对照组升高,差异有统计学意义(P<0.05),两组后循环梗死(posterior circulation infarction,POCI)患者治疗14 d后NIHSS评分和BI评分差异无统计学意义(P<0.05)。治疗后,观察组TACI、PACI患者总有效率高于对照组,差异有统计学意义(P<0.05),两组LACI、POCI间总有效率差异无统计学意义(P>0.05)。两组治疗期间均未发生严重不良反应。结论丁苯酞注射液治疗急性缺血性脑个中可显著改善神经功能和疗效,更适合TACI和PA-CI患者。Objective To observe the effect of butylphthalide injection in patients with acute,ischemic stroke of differ ent OCSP subtypes.Methods Sixty-eight patients with acute ischemic stroke admitted to our hospital from Novem ber 30,2018 to May 30,2019 were enrolled as the observation group,and 68 patients with acute ischemic stroke were selected as control group.The control group received conventional acute ischemic stroke treatment,and the ob servation group received butylphthalide injection on the basis of the control group.All patients underwent OCSP typ ing.The NIHSS scores and BI scores and treatment effects of the two groups of patients and different OCSP patients before and after treatment were observed.Results There was no significant difference in NIIISS scores and BI scores between the two groups before treatment(P>0.05).At 14 days after treatment,the NIHSS score of the observation group was lower than that of the control group,the BI score was higher than that of the control group,the total effec tive rate was higher than that of the control group,and the difference was statistically significant(P<0.05).The NI HSS scores of the patients with different OCSP classifications in the observation group and the control group were lower than those before treatment,and the BI scores were significantly higher than those before treatment(P<0.05).Compared with the control group,the NIHSS scores of the TACK PACK LACI patients in the observation group were significantly lower than those in the control group,and the BI scores were significantly higher than those in the con trol group(P<0.05).There was no significant difference in NIHSS’scores and BI scores between the two groups of POCI patients after 14 days of treatment(P<0.05).After treatment,the total effective rate of TACI and PACI pa tients in the observation group was higher than that in the control group(P<0.05).There was no significant differ ence in the total effective rate between the two groups of patients with LACI and POCI(P>0.05).No serious adverse reactio

关 键 词：丁苯酞注射液 OCSP亚型 疗效 急性缺血性脑卒中 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]