恩替卡韦联合聚乙二醇干扰素脉冲疗法与全程疗法治疗慢性乙型肝炎的效果比较  

Comparing the Curative Effect of Whole Course and Pulse Therapy of Pegylated Interferon Combined with Entecavir on Chronic Hepatitis B

作　　者：杨晓艳[1] 张国强[1] 李国涛[1] 朱豫萌 张盼[1] 刘雯[1] 朱丹燕[1] YANG Xiao-yan;ZHANG Guo-qiang;LI Guo-tao;ZHU Yu-meng;ZHANG Pan;LIU Wen;ZHU Dan-yan(Department of Infectious Disease,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)

机构地区：[1]郑州大学附属洛阳市中心医院感染科,河南洛阳471000

出　　处：《河南医学研究》2020年第10期1750-1752,共3页Henan Medical Research

基　　金：河南省科技攻关项目(2018020914)。

摘　　要：目的比较恩替卡韦联合聚乙二醇干扰素脉冲疗法与全程疗法对慢性乙型肝炎的效果。方法选取2017年8月至2018年5月就诊于郑州大学附属洛阳市中心医院的50例慢性乙型肝炎患者(HBsAg、HBeAg均为阳性),采用抽签法将患者分为对照组(25例)和观察组(25例)。在口服原有核苷类似物(恩替卡韦分散片)的基础上,给予对照组患者全程应用聚乙二醇干扰素α-2b注射液治疗,对观察组患者每间隔3个月应用聚乙二醇干扰素α-2b注射液治疗,疗程为1 a。比较两组治疗前后HBsAg定量、HBsAg阴转率、HBeAg血清学转换率。结果两组治疗后HBsAg定量比较,差异无统计学意义(P>0.05)。治疗后,两组HBsAg定量均低于治疗前,差异有统计学意义(均P<0.05)。对照组和观察组HBsAg阴转率分别为20.0%(5/25)、24.0%(6/25)。对照组和观察组HBeAg血清学转换率分别为76.0%(19/25)、72.0%(18/25)。两组HBsAg阴转率、HBeAg血清学转换率比较,差异无统计学意义(均P>0.05)。结论在恩替卡韦分散片的基础上,聚乙二醇干扰素间断脉冲疗法与全程疗法对慢性乙型肝炎的效果相当。Objective To compare the effect of whole course and pulse therapy of pegylated interferon combined with entecavir on chronic hepatitis B.Methods Fifty patients with chronic hepatitis B(HBsAg and HBeAg positive) who visited Luoyang Central Hospital Affiliated to Zhengzhou University from August 2017 to May 2018 were selected and divided into control group(25 cases) and observation group(25 cases) by drawing lots. On the basis of oral administration of the original nucleoside analogue(entecavir dispersible tablets), the patients in control group were treated with pegylated interferon-α-2 b injection in the whole process, and the patients in observation group were treated with pegylated interferon-α-2 b injection every 3 months. The course of treatment was 1 year. The HBsAg quantification, negative conversion rate of HBsAg and serological conversion rate of HBeAg were compared between the two groups.Results There was no significant difference in HBsAg quantification between the two groups after treatment(P>0.05). After treatment, the HBsAg quantitation in the two groups was lower than that before treatment, and the differences were statistically significant(both P<0.05). The negative conversion rates of HBsAg in control group and observation group were 20.0%(5/25) and 24.0%(6/25), respectively. The serological conversion rates of HBeAg in control group and observation group were 76.0%(19/25) and 72.0%(18/25), respectively. There were no significant differences in the negative conversion rate of HBsAg and the serological conversion rate of HBeAg between the two groups(both P>0.05).Conclusion Based on entecavir dispersible tablets, the effect of intermittent pulse therapy with pegylated interferon on chronic hepatitis B is equivalent to whole-course therapy.

关 键 词：慢性乙型肝炎 聚乙二醇干扰素 恩替卡韦 HBsAg阴转率 HBeAg血清学转换率 

分 类 号：R575.1[医药卫生—消化系统]